Indiana University School of Medicine cancer researchers who have been working to lessen the side effects caused by chemotherapy have been awarded $2.3 million to continue their studies.
Jill Fehrenbacher and Mark Kelley are recipients of the five-year grant (1R01CA231267) from NCI, which will enable them to continue their studies on chemotherapy-induced peripheral neuropathy.
The researchers will test the effectiveness of a small, targeted molecule called APX3330 to prevent or reverse CIPN caused by cancer drugs in tumor-bearing mice.
“For patients with CIPN, this might be an option for pain relief or neuropathic symptom relief in the future,” said Fehrenbacher, associate professor of pharmacology and toxicology at IU School of Medicine and a researcher at the IU Simon Cancer Center. “Alternatively, for patients undergoing chemotherapy treatments, it might be something we can administer alongside the chemotherapy drugs so they never develop CIPN.”
Currently, there are no effective treatments or preventive treatments against neuropathy because researchers don’t yet understand all of the mechanisms that lead to it. It is believed that neuropathy develops over time as a cumulative effect of chemotherapy that alters the function of sensory neurons, which are responsible for detecting pain and touch.
In 2017, Kelley, associate director of basic science research at the IU Simon Cancer Center, was first awarded a $2.9 million grant (1R01CA205166) from NCI to study CIPN. Fehrenbacher is also a co-principal investigator of that initial grant. That grant was awarded because Kelley, Fehrenbacher, and colleagues had previously demonstrated in the lab that increasing the repair activity of a protein called APE1/Ref-1 decreased neurotoxicity.
The aims of the 2017 grant are to study, in detail, the mechanisms by which APE1 alters the function of the sensory neurons. Interestingly, they also found that APX3330 was effective in reducing APE1’s ability to facilitate the growth and spread of tumors in mice models, therefore this new drug has the potential to block the advancement of cancer and CIPN.
APX3330 is currently in phase I trials, supported by Apexian Pharmaceuticals, to test its safety for people. Kelley is a co-founder and chief scientific officer at Apexian, which plans to advance APX3330 for phase II trials for anti-tumor and anti-CIPN studies.
APX3330 was developed based on Kelley’s nearly three decades of cancer research.
NCI awarded both grants as part of its Provocative Questions initiative, a program aimed at promoting cancer-related research on important yet understudied areas or research questions that have proven difficult to address.
Three years ago, researchers from Memorial Sloan Kettering Cancer Center published stunning results: For the 5% of rectal cancer patients whose tumors are mismatch-repair deficient, neoadjuvant dostarlimab-gxly (Jemperli) has the makings of a silver bullet.
