Immunomedics expands clinical collaboration with AstraZeneca to include metastatic NSCLC

Share on facebook
Share on twitter
Share on linkedin
Share on email
Share on print

The clinical collaboration between Immunomedics Inc. and AstraZeneca and MedImmune for the development of Imfinzi (durvalumab) and sacituzumab govitecan combination therapy has been broadened to include second-line metastatic non-small cell lung cancer, the companies said.

“The combination study with durvalumab, together with our internal efforts to further develop sacituzumab govitecan monotherapy, will help us define the best registration strategies in NSCLC within accelerated timelines,” said Robert Iannone, head of research & development and chief medical officer of Immunomedics.

As CPIs increasingly move into front-line therapy, either alone or in combination with chemotherapy, treatment options for second-line and beyond are limited to single agent chemotherapies, which have only very modest activity. Thus, there is a high unmet need in NSCLC for patients who don’t respond or have progressed after treatment with CPIs.

Sacituzumab govitecan as monotherapy has produced an overall response rate of 19 percent in 47 patients with pretreated metastatic NSCLC with a duration of response of 6.0 months. In a subgroup of patients (14 of 47 patients) who had previously been treated with CPIs as their last line of therapy, ORR was 14 percent (2/14).

This open-label, multi-center phase I/II study will enroll two cohorts of patients, one in CPI primary refractory, and one in acquired resistance to CPI.

Sacituzumab govitecan, Immunomedics’ most advanced product candidate, is a novel, first-in-class antibody-drug conjugate. It is currently under priority review by the FDA for accelerated approval as a treatment of patients with metastatic triple-negative breast cancer who have received two prior therapies for metastatic disease. If approved, sacituzumab govitecan would be the first and only ADC approved for the treatment of metastatic triple-negative breast cancer.

Durvalumab is a human monoclonal antibody that binds to PD-L1 and blocks the interaction of PD-L1 with PD-1 and CD80, countering the tumor’s immune-evading tactics and releasing the inhibition of immune responses.

As part of a broad development program, durvalumab is being investigated as monotherapy and in combination with IO, small molecules, and chemotherapies across a range of tumors and stages of disease.

Table of Contents

YOU MAY BE INTERESTED IN

I was really excited to get to talk about the role that mentorship plays in women’s leadership development. It’s a topic that I’ve thought a lot about, and also that I’ve benefitted from, and that I think is not always applied with enough intention. There is an art to mentorship, and I want to share some of how that has helped me navigate career transitions and pivot to leadership roles.

Never miss an issue!

Get alerts for our award-winning coverage in your inbox.

Login