Guardant Health and OncoMed Pharmaceuticals will collaborate using Guardant Health’s digital sequencing technology to develop a custom blood test that looks for specific biomarkers relevant to OncoMed’s ongoing phase Ia/Ib trial of its anti-RSP03 antibody. RSPO3 gene overexpression, including RSPO3 gene fusions, appear to drive tumor growth in subsets of several cancers, including colon, ovarian,...
A group of melanoma experts, joined by three advocacy groups focused on melanoma, has engaged FDA in a public discussion of the challenges of developing new drugs in the refractory setting and the role crossover can play in such trials.
