TERAVOLT registry tracks outcomes of treatments among thoracic cancer patients with COVID-19

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New data from TERAVOLT, a global consortium that tracks outcomes of people with thoracic cancers affected by COVID-19, could demonstrate why thoracic cancer patients experienced a high death rate of 33% when COVID-19 swept across Europe.

While the majority of those who died were hospitalized, only 9% were admitted to intensive care units, according to a study published June 12 in The Lancet Oncology. Most died from complications of COVID-19, not the progression of cancer.

“Just having a lung cancer diagnosis in and of itself shouldn’t exclude patients from care,” senior author Leora Horn, Ingram Associate Professor of Cancer Research at Vanderbilt-Ingram Cancer Center and TERAVOLT consortium steering committee member, said in a statement.

The study is based on the first 200 patients for whom TERAVOLT received outcomes data. Of the 152 hospitalized patients, 134, or 88%, met the criteria for ICU admission, but only 13 of those patients were admitted to an ICU. Only five were mechanically ventilated.

Most of the patients were hospitalized in Italy, France and Spain. The study’s lead author, Marina Garassino, of the National Cancer Institute of Milan, initiated the idea for the registry, which led to the TERAVOLT consortium (Thoracic cancERs InterAtional coVid 19 cOLlobaraTion).

“We tried to capture the reasons for the lack of ICU admission,” the authors noted in the study. “Difficult decisions were made limiting ICU admissions to cancer patients and others with terminal illness due to equipment and personnel shortages. However, we are aware that behind these choices there may also be patients’ decisions, cultural and institutional choices that our work is unable to properly capture.”

“Not all lung cancer patients are at risk for hospitalization,” Horn said.

Initial data indicated that patients on tyrosine kinase inhibitors appeared to be at decreased risk for hospital admission. This remained true when Horn presented updated data from the TERAVOLT registry last month at the virtual annual meeting of the American Society of Clinical Oncology. The data presented at the ASCO meeting were based on those first 200 patients in The Lancet Oncology study, plus an additional 200, including many from the United States.

That data revealed that patients treated with chemotherapy within three months of a COVID-19 diagnosis had a significantly increased risk—64%—of dying from the coronavirus. Patients treated with anticoagulants to prevent blood clots and corticosteroids to reduce inflammation also had a greater mortality risk. Patients treated with immunotherapies had no increased risk of mortality.

It remains unclear if intubation and more aggressive care could improve survival for people with thoracic cancers sickened by COVID-19. Patients preferences could provide guidance for clinicians.

The TERAVOLT registry is an ongoing longitudinal study. Data collected from consortium participants across the globe are entered on a REDCap database hosted by Vanderbilt. The registry recently received $95,000 in funding support from the International Association for the Study of Lung Cancer on behalf of the Lung Ambition Alliance.

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