Botensilimab + balstilimab showed no CRC recurrences in resectable colon cancer, phase II NEST trial shows

Retesting with at-home FIT tests is linked to earlier diagnoses, retrospective cohort study finds

Repeat testing is tied to earlier diagnoses and shaped by health-system outreach, according to a retrospective cohort study of nearly 500,000 adults.

July 24, 2026

Vol.52 No.29

Podcast

A new diagnostic lens—and a lasting scientific legacy

In this week's episode of The Cancer Letter Podcast, editor and publisher Paul Goldberg, and associate editor Jacquelyn Cobb revisit two of last week’s most-read stories: the growing recognition that early-onset colorectal cancer requires a new diagnostic mindset, and the life and legacy of Maura Gillison, the scientist whose discovery that most head and neck cancers are driven by HPV transformed the field.

July 08, 2026

Vol.52 No.26

Clinical

Early-onset colorectal cancer is behaving like a new, biologically distinct disease, researchers note
One woman’s pregnancy shows how this distinction matters

Jenna Scott was 29, seven months pregnant, and suddenly, feeling very sick.

July 02, 2026

Vol.52 No.26

By Claire Marie Porter

Clinical Trials & Tribulations

Is it time to re-assess the practice and practicality of screening colonoscopy?
Modeling data, ACS guideline support greater use of noninvasive tests to ease system strain, help save lives

I performed my first colonoscopy as a board-certified gastroenterologist more than 20 years ago, at a time when the procedure was firmly established as the “gold standard” for colorectal cancer screening.

July 02, 2026

Vol.52 No.26

By Paul J. Limburg

Clinical Trials & Tribulations

More than 50 million Americans remain unscreened for colon cancer
New guidelines offer another option

For decades, we have faced a central challenge in colorectal cancer screening. One in three eligible Americans—over 50 million people—remain unscreened despite established methods like colonoscopy or stool-based tests existing for decades. This gap persists even though early detection saves lives, and even as colorectal cancer is now the number one cancer killer for Americans under 50.

Labcorp and Alliance partner to support multi-institution trial to expand genetic testing in CRC

Labcorp and the Alliance for Clinical Trials in Oncology will collaborate on a national, multicenter clinical trial for patients newly diagnosed with colorectal cancer.

June 05, 2026

Vol.52 No.22

Botensilimab + balstilimab showed no CRC recurrences in resectable colon cancer, phase II NEST trial shows

YOU MAY BE INTERESTED IN

Retesting with at-home FIT tests is linked to earlier diagnoses, retrospective cohort study finds

A new diagnostic lens—and a lasting scientific legacy

Early-onset colorectal cancer is behaving like a new, biologically distinct disease, researchers note
One woman’s pregnancy shows how this distinction matters

Is it time to re-assess the practice and practicality of screening colonoscopy?
Modeling data, ACS guideline support greater use of noninvasive tests to ease system strain, help save lives

More than 50 million Americans remain unscreened for colon cancer
New guidelines offer another option

Labcorp and Alliance partner to support multi-institution trial to expand genetic testing in CRC

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Botensilimab + balstilimab showed no CRC recurrences in resectable colon cancer, phase II NEST trial shows

YOU MAY BE INTERESTED IN

Retesting with at-home FIT tests is linked to earlier diagnoses, retrospective cohort study finds

A new diagnostic lens—and a lasting scientific legacy

Early-onset colorectal cancer is behaving like a new, biologically distinct disease, researchers noteOne woman’s pregnancy shows how this distinction matters

Is it time to re-assess the practice and practicality of screening colonoscopy?Modeling data, ACS guideline support greater use of noninvasive tests to ease system strain, help save lives

More than 50 million Americans remain unscreened for colon cancerNew guidelines offer another option

Labcorp and Alliance partner to support multi-institution trial to expand genetic testing in CRC

Never miss an issue!

Login

Early-onset colorectal cancer is behaving like a new, biologically distinct disease, researchers note
One woman’s pregnancy shows how this distinction matters

Is it time to re-assess the practice and practicality of screening colonoscopy?
Modeling data, ACS guideline support greater use of noninvasive tests to ease system strain, help save lives

More than 50 million Americans remain unscreened for colon cancer
New guidelines offer another option