AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution

Elizabeth Mittendorf elected ASCO president for 2026-2027 term

The American Society of Clinical Oncology elected Elizabeth A. Mittendorf to lead as its president beginning in June 2026. Mittendorf, a long-time ASCO member and volunteer, will take office as president-elect immediately following the ASCO Annual Business Meeting in Chicago on June 2.

January 17, 2025

Vol.51 No.02

Clinical Roundup

Trastuzumab emtansine improves OS in HER2+ breast cancer, phase III study shows

In patients with high-risk HER2-positive breast cancer, post-surgery, or adjuvant, treatment with trastuzumab emtansine, also referred to as T-DM1) reduced the long-term risk of death or invasive disease by 46% and improved survival compared to trastuzumab alone, according to the final results of the phase III KATHERINE clinical trial led by researchers from the University of Pittsburgh and UPMC Hillman Cancer Center.

January 17, 2025

Vol.51 No.02

Clinical Roundup

AI improves breast cancer diagnosis

Artificial Intelligence can improve breast cancer detection and reduce workload on physicians, according to a new study featuring over 461,000 women. The research published in the journal Nature Medicine looked at integrating an AI tool as part of a national screening program for women without symptoms of breast cancer in Germany.

January 17, 2025

Vol.51 No.02

Clinical Roundup

Drug in clinical trials for breast cancer could also treat some blood cancers, studies show

Two new studies led by researchers at Washington University School of Medicine in St. Louis have identified a possible way to block the progression of several forms of blood cancer using a drug already in clinical trials against breast cancer.

January 17, 2025

Vol.51 No.02

Clinical Roundup

Breast cancer-causing gene predisposes Black women to TNBC

UC Davis Comprehensive Cancer Center researcher Sanchita Bhatnagar and her team have been working to get to the bottom of the genetic determinants of the racial disparity in triple-negative breast cancer.

January 17, 2025

Vol.51 No.02

White House

Fran Visco awarded the Presidential Citizens Medal: “We are not going to change what we do or how we do it.”

Credit for photos: White HouseIn 1992, 44-year old Philly trial lawyer and breast cancer survivor, Fran Visco, took the stand before the Senate Labor, HHS, Education Appropriations Subcommittee, asserting a tone and stance previously unfamiliar in the world of cancer groups asking for funding before Congress.

January 10, 2025

Vol.51 No.01

By Claire Marie Porter