The Cancer Letter

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Clinical Roundup

From scorpion to immunotherapy: City of Hope scientists repurpose toxin for first-of-its kind CAR-T cell therapy for brain tumors

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City of Hope scientists have developed and tested the first chimeric antigen receptor therapy using chlorotoxin, a component of scorpion venom, to direct T cells to target brain tumor cells, according to a preclinical study published March 4 in Science Translational Medicine. The institution has also opened the first in-human clinical trial to use the therapy.

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