George Sledge responds to Berry’s letter: Neoadjuvant doesn’t predict adjuvant in breast cancer and Berry’s rejoinder

As always, I both enjoyed and learned something interesting from Dr. Don Berry, one of the great biostatisticians of our era. I find, reading his analysis of ALTTO and NeoALTTO, much that I agree with. I am certainly no statistician, and must bow to his statistical analysis of ALTTO and NeoALTTO. And yet at the same time I think it misses the point. So I will beg to differ.

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Byline

George W. Sledge Jr.

Chief of oncology, Stanford University

Donald A. Berry

Professor of biostatistics, MD Anderson Cancer Center

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Table of Contents

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White House

Rathmell steps down at NCI as Trump team considers candidates to replace her
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W. Kimryn Rathmell has stepped down as NCI director, opting to hand her resignation to the Biden administration over facing the uncertainties that Trump and his team are expected to usher in starting next week.

January 17, 2025

Vol.51 No.02

By Paul Goldberg

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FDA and OHRP draft guidance aims to improve ethics of tissue biopsies in clinical trials

The U.S. Food and Drug Administration and the U.S. Department of Health and Human Services Office of Human Research Protections issued Draft Guidance on the inclusion of tissue biopsies in clinical trials.

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Vol.51 No.02

By Laura A. Levit, Mark J. Ratain, Julie R. Gralow, Clifford A. Hudis and Elizabeth Garrett-Mayer

ACS report: Cancer mortality continues to drop despite rising incidence in women

Despite steady progress in reducing overall cancer mortality rates, cancer incidence in women is rising, according to the American Cancer Society’s “Cancer Statistics, 2025” report. Incidence rates in women 50-64 years of age have surpassed those in men, and rates in women under 50 are now 82% higher than their male counterparts, up from 51% higher in 2002. In 2021, for the first time, lung cancer incidence was higher in women under 65 than in men.

January 17, 2025

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By Yiqing Wang

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Cedars-Sinai Cancer’s model of care ensured patient care amid wildfires

Over the past five years, Cedars-Sinai Cancer has built an integrated, regional system designed to provide cancer care close to where patients live and work. This model of care, directed by an academic medical center to patients at the community level, proved to be the best possible approach to supporting patients in our 11-million-person catchment area during the worst fire disaster in California history.

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By Dan Theodorescu, Robert A. Figlin, Howard M. Sandler and Joan August

Clinical

NCCN publishes patient resource on genetic testing to guide patient decisionmaking

The National Comprehensive Cancer Network published its first patient resource aimed at informing people about the latest recommendations around hereditary and familial cancer risk. The document provides guidance on testing for inherited genetic mutations that can raise the risk of cancer.

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By Jacquelyn Cobb

Clinical Trials & Tribulations

Chadi Nabhan: Why I wrote a book about cancer

Almost all of us who have practiced oncology for years have encountered situations where we have had to counsel caregivers and guide them throughout their loved ones’ journeys. We have faced patients who took complementary therapies to an extreme; some to a point where they wouldn’t share what they were taking for fear that we might demand they stop.

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George Sledge responds to Berry’s letter: Neoadjuvant doesn’t predict adjuvant in breast cancer and Berry’s rejoinder

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Rathmell steps down at NCI as Trump team considers candidates to replace her
Wafik El-Deiry, Harvey Risch have been interviewed

FDA and OHRP draft guidance aims to improve ethics of tissue biopsies in clinical trials

ACS report: Cancer mortality continues to drop despite rising incidence in women

Cedars-Sinai Cancer’s model of care ensured patient care amid wildfires

NCCN publishes patient resource on genetic testing to guide patient decisionmaking

Chadi Nabhan: Why I wrote a book about cancer

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George Sledge responds to Berry’s letter: Neoadjuvant doesn’t predict adjuvant in breast cancer and Berry’s rejoinder

YOU MAY BE INTERESTED IN

Rathmell steps down at NCI as Trump team considers candidates to replace herWafik El-Deiry, Harvey Risch have been interviewed

FDA and OHRP draft guidance aims to improve ethics of tissue biopsies in clinical trials

ACS report: Cancer mortality continues to drop despite rising incidence in women

Cedars-Sinai Cancer’s model of care ensured patient care amid wildfires

NCCN publishes patient resource on genetic testing to guide patient decisionmaking

Chadi Nabhan: Why I wrote a book about cancer

Never miss an issue!

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Rathmell steps down at NCI as Trump team considers candidates to replace her
Wafik El-Deiry, Harvey Risch have been interviewed