Donald A. Berry
Donald A. Berry, PhD

Professor, founding chair, Department of Biostatistics, Division of Basic Sciences, MD Anderson Cancer Center; Senior statistical scientist, founder, Berry Consultants, LLC

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Our good friend and colleague Ed Gehan passed away on Sept. 28 at the age of 92. Ed and his contributions to cancer research and to cancer patients are legend.
An article in the June 6 issue of The Cancer Letter described plenary presentations at ASCO 2014. One presentation was the adjuvant breast cancer clinical trial ALTTO in HER2-positive disease, which “was chosen [for the plenary session] because it addressed the reliability of pathological complete response as a surrogate for patient benefit.” The article and much ASCO and post-ASCO rhetoric in the breast cancer community focused on the conclusion that ALTTO failed to show a statistically significant benefit in disease-free survival (DFS) for combination lapatinib/trastuzumab in comparison with trastuzumab, both on a backbone of chemotherapy. This was despite a statistically significant benefit in pathological complete response (pCR) in NeoALTTO, the neoadjuvant version of ALTTO.

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