Rewriting immune regulation with the CD6/CTLA‑4 CAR‑Treg platform

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A new way to treat immune‑driven disease

Autoimmune and inflammatory diseases arise when the immune system becomes misdirected, attacking the tissues it is meant to protect. 

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Christine Brown, PhD
Heritage Provider Network Professor in Immunotherapy, Deputy Director, T Cell Therapeutics Research Laboratories, City of Hope
Enrique Montero, MD, PhD
Research professor, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope
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Researchers from City of Hope have developed a “plug-and-play” technology that adds engineered molecules to chimeric antigen receptor T cells after treatment, allowing scientists to better control the cells and redirect them to attack different types of cancer. The preclinical study offers a more flexible way to help CAR T cells keep pace with mutating tumors.
Christine Brown, PhD
Heritage Provider Network Professor in Immunotherapy, Deputy Director, T Cell Therapeutics Research Laboratories, City of Hope
Enrique Montero, MD, PhD
Research professor, Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope

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