The Cancer Letter

Inside information on cancer research and drug development

NCI Trials

NCI Trials for Oct. 2021

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The National Cancer Institute approved the following clinical research studies last month.  

For further information, contact the principal investigator listed.

Phase I – 10433
Phase I/Ib Trial Evaluating the Safety and Efficacy of BET Inhibitor, ZEN003694 with PD-1 Inhibitor, Nivolumab with or Without CTLA-4 Inhibitor, Ipilimumab in Solid Tumors

UPMC Hillman Cancer Center LAO
Mahdi, Haider Salih
(216) 445-7069

Phase I – 10440
A Phase 1/1a Study of Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for Relapsed/Refractory Light Chain Amyloidosis

City of Hope Comprehensive Cancer Center LAO
Rosenzweig, Michael A.
(626) 256-4673

Phase I – PBTC-059
Phase 1 Trial of Autologous HER2-Specific CAR T Cells in Pediatric Patients with Refractory or Recurrent Ependymoma

Pediatric Brain Tumor Consortium
Hegde, Meenakshi
(832) 824-4840

Phase II – 10466
A Phase 2 Study of Bevacizumab, Erlotinib and Atezolizumab in Subjects with Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) Associated or Sporadic Papillary Renal Cell Cancer

National Cancer Institute LAO
Srinivasan, Ramaprasad
(240) 760-6251

Phase II – 10476
A Randomized Phase 2 Study of Combination Atezolizumab and CDX-1127 (Varlilumab) with or Without Addition of Cobimetinib in Previously Treated Unresectable Biliary Tract Cancers

JHU Sidney Kimmel Comprehensive Cancer Center LAO
Azad, Nilofer Saba
(410) 614-9169

Phase II – A021901
Randomized Phase II Trial of Lutetium Lu 177 Dotatate Versus Everolimus in Somatostatin Receptor Positive Bronchial Neuroendocrine Tumors

Alliance for Clinical Trials in Oncology
Hope, Thomas A.
(415) 353-7065

Phase II – A09200
Phase 2 Randomized Trial of Neoadjuvant or Palliative Chemotherapy with or Without Immunotherapy for Peritoneal Mesothelioma

Alliance for Clinical Trials in Oncology
Mansfield, Aaron S.
(507) 293-0569

Phase II – S1934
NASSIST (Neoadjuvant Chemoradiation +/- Immunotherapy Before Surgery for Superior Sulcus Tumors): A Randomized Phase II Trial of Trimodality +/- Atezolizumab in Resectable Superior Sulcus Non-Small Cell Lung Cancer

SWOG
Osarogiagbon, Raymond Uyiosa
(901) 355-6340

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