Mark Kelley, Melissa Fishel receive $2.4M NCI grant to develop pancreatic cancer treatments

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Mark Kelley

Melissa Fishel

Mark Kelley and Melissa Fishel, two researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center, received a five-year, $2.4 million grant from NCI to explore therapies that target the critical pathways pancreatic tumors use to survive.

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Zoldonrasib, an oral RAS(ON) G12D-selective covalent inhibitor, in combination with daraxonrasib showed 81% objective response rate compared to zoldonrasib in combination with standard of care chemotherapy in previously untreated patients with RAS G12D metastatic pancreatic ductal adenocarcinoma, according to results of two phase I/II study. 

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