NCCN guidelines detail fundamental differences between pediatric and adult cancers

James Downing to step down as president and CEO of St. Jude to focus on global pediatric medicine

After leading unprecedented growth of St. Jude Children’s Research Hospital over the past 12 years, James R. Downing will step down as president and CEO in late 2026 as part of a planned leadership transition, St. Jude officials said.

February 20, 2026

Vol.52 No.07

Clinical Roundup

NCCN updates guidelines recognizing MammaPrint to guide personalized anthracycline use in HR+/HER2- early‑stage breast cancer

The NCCN added MammaPrint + BluePrint to the Clinical Practice Guidelines in Oncology for the identification of a subset of hormone receptor positive, HER2-negative early-stage breast cancer patients most likely to benefit from anthracycline-based chemotherapy.

February 06, 2026

Vol.52 No.05

Drugs & Targets

Trodelvy added to NCCN guidelines as preferred regimen option for first-line metastatic TNBC

Trodelvy (sacituzumab govitecan-hziy) was added to the NCCN Guidelines as a category 1 preferred first-line treatment option for people with metastatic triple-negative breast cancer whose disease is PD-L1 negative (CPS <10) and no germline BRCA1/2 PV.

January 30, 2026

Vol.52 No.04

Capitol Hill

Fifth time’s a charm? Mikaela Naylon Give Kids a Chance Act is included in FY26 spending bill

Sometime next week, the Senate is expected to vote on a legislative package that would determine the fiscal year 2026 spending levels for much of the federal government.

Nancy Goodman: “Sen. Sanders says he cares about kids with cancer. I’m just asking him to show us.”

On Dec. 19, the Mikaela Naylon Give Kids a Chance Act was blocked in the Senate by Sen. Bernie Sanders (I-VT) after receiving unanimous approval from the U.S. House of Representatives Dec. 1.

January 07, 2026

Cancer Policy

Mikaela Naylon Give Kids a Chance Act nixed by Senate

The U.S. Senate didn’t take up the Mikaela Naylon Give Kids a Chance Act after two Senate members—Bernie Sanders (I-VT) and Sen. Markwayne Mullin (R-OK)— voted “Nay,” blocking it.

December 19, 2025

Vol.51 No.46

By Claire Marie Porter

NCCN guidelines detail fundamental differences between pediatric and adult cancers

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James Downing to step down as president and CEO of St. Jude to focus on global pediatric medicine

NCCN updates guidelines recognizing MammaPrint to guide personalized anthracycline use in HR+/HER2- early‑stage breast cancer

Trodelvy added to NCCN guidelines as preferred regimen option for first-line metastatic TNBC

Fifth time’s a charm? Mikaela Naylon Give Kids a Chance Act is included in FY26 spending bill

Nancy Goodman: “Sen. Sanders says he cares about kids with cancer. I’m just asking him to show us.”

Mikaela Naylon Give Kids a Chance Act nixed by Senate

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