Gene therapy that induces the body to create microRNA-22, or miR-22, a naturally occurring molecule, successfully treated mice with hepatocellular carcinoma in a study at the UC Davis Comprehensive Cancer Center. The miR-22 treatment also reduced liver inflammation and produced better survival outcomes compared to the FDA-approved liver cancer treatment lenvatinib.
Long-term results from the phase III CARTITUDE-4 study show a single infusion of Carvykti (ciltacabtagene autoleucel) significantly extended overall survival in patients with relapsed or lenalidomide-refractory multiple myeloma who have received at least one prior line of therapy, including a proteasome inhibitor, reducing the risk of death by 45% versus standard therapies of pomalidomide, bortezomib and dexamethasone or daratumumab, pomalidomide and dexamethasone.
