Enhanced recovery program successfully reduced opioid use after pancreatic cancer surgery

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By improving hospital care pathways, researchers from MD Anderson Cancer Center successfully reduced inpatient opioid use by 50% after pancreatic cancer surgery and cut the median opioid prescription volumes at discharge to zero. 

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Jashodeep Datta, a researcher with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, has been awarded a grant from the U.S. Department of Defense’s Congressionally Directed Medical Research Program to target chemotherapy resistance in pancreatic cancer. The $800,000, three-year grant is the first DoD award to Sylvester to study pancreatic cancer.
Researchers at MD Anderson Cancer Center have uncovered a functional role for KRAS mutations in pancreatic cancer and rapidly translated these findings into a novel therapeutic approach combining a KRAS G12D inhibitor with immune checkpoint inhibitors for early- and late-stage KRAS G12D-mutant pancreatic cancer. The combination therapy led to durable tumor elimination and significantly improved survival outcomes in preclinical models, leading to the launch of a phase I clinical trial.
Research directed by Johns Hopkins showed that for patients with operable pancreatic cancers, a three-pronged combination immunotherapy treatment—consisting of the pancreatic cancer vaccine GVAX, the immune checkpoint therapy nivolumab and urelemab, an anti-CD137 agonist antibody treatment—is safe, increases the amount of cancer-killing immune system T cells in the tumors, and appears effective when given two weeks prior to cancer-removal surgery. A description of the work was published in Nature Communications.