Vol.

No.

December 05, 2025Dec 05, 2025

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Cover Story

Anthony Letai pledges to ensure stability for extramural and intramural cancer science

Stepping into the NCI director’s job at the end of a nerve-racking year, Anthony Letai wants you to know that the federal government is not going out of the business of cancer research.

NCI

In first NCAB director’s report, Anthony Letai focuses on centralized grant review, budget outlook

By Jacquelyn Cobb

Regulatory News

Pazdur leaves FDA after 25-year career that shaped the agency’s oncology regulations
BIO calls for the end of “constant turmoil,” urges the administration to “right the ship”

By Paul Goldberg

Guest Editorial

Mail-out colorectal cancer screening programs extend, rather than replace, clinical care

By Paul J. Limburg

Fixing site reads without burning out the readers
Yunu modernizes clinical trial imaging assessment workflows

By Jeff Sorenson

Podcast

Richard Pazdur left FDA to avoid being part of “the destruction of the American medical system”

Cancer Policy

Pediatric cancer five-year survival rate has increased dramatically, AACR says in inaugural Pediatric Cancer Progress Report

Vinay Prasad to CBER employees: “It is not wise for FDA to further pollute the scientific literature with papers we cannot defend”

FDA releases draft guidance on reducing testing on non-human primates for monoclonal antibodies

Vaccine skeptic installed as CDC’s new second-in-command

CMS cuts deal on four oncology drugs under Medicare

Medicare Part B premiums expected to rise almost 10% in 2026

Hospitals sue to block CMS 340B drug rebate pilot

Trump administration puts new restrictions on federal student loan borrowing

In Brief

Paradigm Health acquires Flatiron Health’s clinical research business

Ben Ho Park, Sara Tolaney to receive awards at 2025 San Antonio Breast Cancer Symposium

Susan G. Komen awards IU’s Komen Tissue Bank $750,000 grant

Kathryn Schmitz, José P. Zevallos named deputy directors of UPMC Hillman Cancer Center

Andres Álvarez-Pinzón, Ronald Chen, Vered Stearns, Alexandra Thomas, Trisha Wise-Drapernamed to NRG Oncology leadership

Jihad Obeid named assistant vice president for research at MUSC

Mark Veich named chief organizational advancement officer of Parker Institute for Cancer Immunotherapy

Christopher Liekweg named associate director of administration at UMich Rogel Cancer Center

Vincent Wu named Casper Wistar Fellow at Vaccine & Immunotherapy Center

UAMS receives $10.5M NIH grant to develop biomarkers through proteomics

Clinical Roundup

ASTRO publishes first guideline focused on radiation therapy for gastric cancer

Montefiore Einstein sees lowest rate of late-stage lung cancer diagnoses in surrounding community

Sylvester researchers lead treatment overhauls for AML

Patients in Nepal experience substantial delays when accessing cancer care, study finds

Drugs & Targets

FDA approves Keytruda and Keytruda Qlex + Padcev as perioperative treatment cisplatin-ineligible bladder cancer

FDA approves durvalumab + FLOT for resectable gastric or gastroesophageal junction adenocarcinoma

FDA grants 501(k) clearance for Vanquish System for prostate tissue ablation in intermediate risk prostate cancer

EC approves expanded use of CAR T-cell therapy Breyanzi for r/r mantle cell lymphoma

Université Paris-Saclay, Owkin partner to use AI co-pilot for biology research

NCI Trials

NCI Trials for December 2025

The National Cancer Institute approved the following clinical research studies last month.

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