NEJM phase III trial of Lonsurf + bevacizumab in CRC shows OS and PFS increases in mCRC

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Results from the multinational, pivotal phase III SUNLIGHT* clinical trial of Lonsurf (trifluridine/tipiracil), alone or in combination with bevacizumab, in refractory metastatic colorectal cancer (mCRC) showed a statistically significant and clinically meaningful improvements in overall survival and progression-free survival for patients with refractory mCRC following disease progression or intolerance on two prior chemotherapy regimens compared to trifluridine/tipiracil alone. 

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In this week's episode of The Cancer Letter Podcast, editor and publisher Paul Goldberg, and associate editor Jacquelyn Cobb revisit two of last week’s most-read stories: the growing recognition that early-onset colorectal cancer requires a new diagnostic mindset, and the life and legacy of Maura Gillison, the scientist whose discovery that most head and neck cancers are driven by HPV transformed the field. 
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