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IMGN853 linked to improved outcomes in (FRα)-high platinum-resistant ovarian cancer

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IMGN853 (mirvetuximab soravtansine) yielded positive top-line data in the pivotal phase III SORAYA trial evaluating the safety and efficacy of the monotherapy in patients with folate receptor alpha (FRα)-high platinum-resistant ovarian cancer who have been previously treated with Avastin (bevacizumab).

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Genmab A/S announced on March 17 updated data from cohort B1 of the phase I/II RAINFOL-01 study of rinatabart sesutecan, an investigational folate receptor-alpha-targeted, TOPO1 antibody-drug conjugate that showed Rina-S 120 mg/m2 every three weeks resulted in a confirmed objective response rate of 55.6% (95% CI: 30.8-78.5) in heavily pre-treated ovarian cancer patients regardless of FRα expression levels. 
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