Napo Pharmaceuticals initiates phase III trial of Mytesi for prophylaxis of diarrhea in adult cancer patients

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Napo Pharmaceuticals Inc., a wholly owned subsidiary of Jaguar Health Inc., has initiated its pivotal phase III clinical trial of crofelemer (Mytesi) for prophylaxis of diarrhea in adult cancer patients receiving targeted therapy.

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I have spent over 20 years running a tumor imaging metrics core at an academic cancer center. In that time, I have watched clinical trial enrollment concentrate at a relatively small number of flagship academic institutions. Unfortunately, trials do not propagate well to the community sites where most patients prefer to receive care. The explanations usually offered for why this happens have never fully accounted for what I observed.

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