The Cancer Letter

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Clinical Roundup

ACE-CL-001, ASCEND trials demonstrate long-term efficacy and tolerability of Calquence in CLL

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In the ACE-CL-001 trial, data showed 97% of previously untreated CLL patients continued to respond to treatment after more than four years with no new safety signals.

In the pivotal ASCEND trial, an estimated 82% of CLL patients with relapsed or refractory disease treated with Calquence remained progression free at 18 months vs. 48% for comparators. Overall, Calquence data delivered meaningful long-term clinical benefit with a favorable safety profile for patients with CLL, regardless of whether they’re new to treatment or are managing relapsed or refractory disease.

A link to the ACE-CL-001 trial abstract can be found here, and the ASCEND trial abstract here.

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