EPA moves to weaken limits of PFAS in drinking water

Breaking down Operation Trailblazer: Rolling INDs, outside expert submission help, and one-trial requirement

In this week’s episode of The Cancer Letter Podcast, Paul Goldberg, editor and publisher of The Cancer Letter, and Sara Willa Ernst, reporter, break down HHS’ latest vision for the future: Operation Trailblazer.

July 01, 2026

Regulatory News

To keep the early clinical trial enterprise in the U.S., HHS pledges to simplify regulatory requirements

HHS earlier this week rolled out a cluster of initiatives related to simplifying clinical trials, presenting these measures as a government-wide effort to maintain America’s leadership in early-stage drug development.

June 26, 2026

Vol.52 No.25

By Paul Goldberg

Kennedy calls for a “moonshot” targeted on the role of the microbiome in cancer

Top HHS officials last week called for a “moonshot” focused on the role of the microbiome in cancer.

HHS rescinds vaccine panel charter citing “administrative error”

The charter governing the Advisory Committee on Immunization Practices will be returned to its previous framework for two years because the Department of Health and Human Services didn’t allow sufficient time for public comment after Robert F. Kennedy crafted a charter more favorable to his policy preferences.

May 22, 2026

Vol.52 No.20

By Claire Marie Porter

Clinical

FDA clears fruit-flavored vapes, relaxes enforcement on black-market products with pending premarket applications
Critics say policies clear the way for major tobacco companies to enter fruit-flavored vape market

In a recent set of regulatory decisions that culminated in the resignation of FDA Commissioner Marty Makary on May 12, the agency appears to have reversed its hard-ball stance on flavored e-cigarettes.

After a year-long reign over tumult at FDA, Makary heads for the exit
Fruit-flavored e-cigs were the final blow for the commissioner

The immediate impetus for FDA Commissioner Marty Makary’s exit from the top job at FDA is arguably less significant than the legacy of dysfunction he leaves behind.

May 15, 2026

Vol.52 No.19

By Claire Marie Porter

EPA moves to weaken limits of PFAS in drinking water

YOU MAY BE INTERESTED IN

Breaking down Operation Trailblazer: Rolling INDs, outside expert submission help, and one-trial requirement

To keep the early clinical trial enterprise in the U.S., HHS pledges to simplify regulatory requirements

Kennedy calls for a “moonshot” targeted on the role of the microbiome in cancer

HHS rescinds vaccine panel charter citing “administrative error”

FDA clears fruit-flavored vapes, relaxes enforcement on black-market products with pending premarket applications
Critics say policies clear the way for major tobacco companies to enter fruit-flavored vape market

After a year-long reign over tumult at FDA, Makary heads for the exit
Fruit-flavored e-cigs were the final blow for the commissioner

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EPA moves to weaken limits of PFAS in drinking water

YOU MAY BE INTERESTED IN

Breaking down Operation Trailblazer: Rolling INDs, outside expert submission help, and one-trial requirement

To keep the early clinical trial enterprise in the U.S., HHS pledges to simplify regulatory requirements

Kennedy calls for a “moonshot” targeted on the role of the microbiome in cancer

HHS rescinds vaccine panel charter citing “administrative error”

FDA clears fruit-flavored vapes, relaxes enforcement on black-market products with pending premarket applicationsCritics say policies clear the way for major tobacco companies to enter fruit-flavored vape market

After a year-long reign over tumult at FDA, Makary heads for the exitFruit-flavored e-cigs were the final blow for the commissioner

Never miss an issue!

Login

FDA clears fruit-flavored vapes, relaxes enforcement on black-market products with pending premarket applications
Critics say policies clear the way for major tobacco companies to enter fruit-flavored vape market

After a year-long reign over tumult at FDA, Makary heads for the exit
Fruit-flavored e-cigs were the final blow for the commissioner