IU cancer center researcher leads first-in-human multiple myeloma study with 90.5% response rate

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In a first-in-human clinical trial for patients with relapsed multiple myeloma, led by researchers at Indiana University Melvin and Bren Simon Comprehensive Cancer Center, patients treated with higher doses of the immunotherapy called REGN5459 resulted in a 90.5% overall response rate. 

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Long-term results from the phase III CARTITUDE-4 study show a single infusion of Carvykti (ciltacabtagene autoleucel) significantly extended overall survival in patients with relapsed or lenalidomide-refractory multiple myeloma who have received at least one prior line of therapy, including a proteasome inhibitor, reducing the risk of death by 45% versus standard therapies of pomalidomide, bortezomib and dexamethasone or daratumumab, pomalidomide and dexamethasone. 

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