Cofactor Genomics has launched an RNA-based immune profiling kit developed for laboratories wishing to derive the immune composition of tumor samples.
Using the ImmunoPrism Immune Profiling Kit, laboratories now have access to the same kit Cofactor Genomics uses to prep, sequence and analyze against Cofactor’s database of machine-learning optimized immune reference expression models.
The launch of the kit follows recent ImmunoPrism announcements on collaborations with The Fred Hutchinson Cancer Research Center and NCI, and most recently, the clinical accreditation of the assay by the College of American Pathologists within Cofactor’s CAP/CLIA lab.
Building on data from thousands of RNA expression profiles, the fully analyzed, proprietary, biomarker discovery report includes quantitative immune cell characterizations and enables intra- and inter-sample immune cell ratios and comparisons, which have been shown to have prognostic value. The report also includes statistics such as p-value, threshold for patient selection, predictive accuracy, and positive/negative predictive values, the company said.
Cofactor’s ImmunoPrism Immune Profiling Kit details the quantitative percentage for eight major immune cell types and expression levels of ten immune escape genes. This immune characterization can be obtained using FFPE, FNAs, CNBs, accommodating solid tumors with very limited amounts of tissue, in some cases as low as 20 nanograms. This includes pre-treatment clinical samples, which previously have been difficult to characterize, the company said.
