Barriers to clinical trial enrollment

Part I of a two-part series

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According to the National Cancer Institute (NCI), 1,735,350 people were newly diagnosed with cancer in 2018. Of those, 65% are expected to achieve remission from their cancer 1.

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If you listen to GRAIL executives discuss the results of the long-awaited trial of the company’s multicancer detection test, you might be led to conclude that the company’s pivotal NHS-Galleri study had an overwhelmingly positive result.
Undeterred by the negative topline result of its pivotal trial of Galleri, a multicancer detection test, the test’s sponsor, GRAIL, said it’s forging ahead with its plan to get FDA approval and reimbursement from CMS and private insurers.
Philip E. Castle, director of the NCI Division of Cancer Prevention, said he was disappointed to hear that GRAIL’s NHS-Galleri trial did not meet its primary endpoint of reduction in late-stage cancers.
Daniel Wall, BSc
Research administrator, Marshfield Clinic
Stephanie Engelien, RN, MSN
Oncology research nurse, Marshfield Clinic
Adedayo A. Onitilo, MD, PhD, MSCR, FACP
Director, Oncology/Hematology
and Radiation Oncology Service Line; Department chair, Oncology/Hematology, Marshfield Clinic

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