Loss of Y chromosome “cripples” immune cells, University of Arizona researcher finds

Cells with LOY may induce LOY in otherwise healthy cells—a finding that could explain variability in CAR T-cell therapy response

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Two years ago, Dan Theodorescu made a discovery that could alter biology textbooks: The Y chromosome, widely considered to be a “functional wasteland,” has functions beyond sex determination—and in fact plays a role in cancer biology. 

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Jacquelyn Cobb
Associate Editor
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Jacquelyn Cobb
Associate Editor

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