FDA withdraws proposed rule for asbestos testing in talc-based cosmetics It’s anyone’s guess whether the agency is preparing to strengthen or relax talc regulation

Otis Brawley looks back on a year of great science and greater challenges

In a year that brought us new KRAS-inhibiting drugs, deepened our understanding of HER2 in breast cancer, and highlighted new potential for mRNA vaccines, the cancer field was also rocked by uncertainty of the future of research funding, equity in cancer delivery, and the integrity of review at FDA.

December 31, 2025

Cancer Policy

Angelo de Claro named acting director of FDA Oncology Center of Excellence

Angelo de Claro was named acting director of the FDA Oncology Center of Excellence, following Richard Pazdur’s departure from that position—and the agency (The Cancer Letter, Dec. 5, 2025).

Drug combination kills OVCAR3 ovarian cancer cells, UNM researchers find

With vague symptoms and no screening test, ovarian cancer can be deadly. According to NCI’s Surveillance, Epidemiology and End Results program, 20,890 people will receive an ovarian cancer diagnosis in 2025 and of these, more than half will learn that their ovarian cancer has spread to distant organs.

December 19, 2025

Vol.51 No.46

Drugs & Targets

FDA grants regular approval to rucaparib for metastatic castration-resistant prostate cancer

FDA has approved rucaparib (Rubraca) for adults with a deleterious BRCA mutation (germline and/or somatic)-associated metastatic castration-resistant prostate cancer previously treated with an androgen receptor-directed therapy.

December 19, 2025

Vol.51 No.46

Drugs & Targets

FDA and OS Therapies hold Type C meeting regarding phase IIb clinical trial of OST-HER2 in the prevention or delay of recurrent, fully resected, pulmonary metastatic osteosarcoma

FDA and OS Therapies held a Type C meeting regarding the phase IIb human clinical trial of OST-HER2 in the prevention or delay of recurrent, fully-resected, pulmonary metastatic osteosarcoma.

December 19, 2025

Vol.51 No.46

Drugs & Targets

FDA awards National Priority Voucher to Tecvayli+Darzalex based on phase III study results

FDA has awarded a National Priority Voucher to teclistamab (Tecvayli) in combination with daratumumab (Darzalex) for relapsed/refractory multiple myeloma. This brings the total number of products receiving an award under the Commissioner’s National Priority Voucher pilot program to 16.

December 19, 2025

Vol.51 No.46

FDA withdraws proposed rule for asbestos testing in talc-based cosmetics

It’s anyone’s guess whether the agency is preparing to strengthen or relax talc regulation

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Otis Brawley looks back on a year of great science and greater challenges

Angelo de Claro named acting director of FDA Oncology Center of Excellence

Drug combination kills OVCAR3 ovarian cancer cells, UNM researchers find

FDA grants regular approval to rucaparib for metastatic castration-resistant prostate cancer

FDA and OS Therapies hold Type C meeting regarding phase IIb clinical trial of OST-HER2 in the prevention or delay of recurrent, fully resected, pulmonary metastatic osteosarcoma

FDA awards National Priority Voucher to Tecvayli+Darzalex based on phase III study results

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