NCI Trials for June 2020

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The National Cancer Institute Cancer Therapy Evaluation Program approved the following clinical research studies last month.

For further information, contact the principal investigator listed.


Phase I – NRG-GI007

Phase I Trial with Expansion Cohort of OBP-301 (Telomelysin) and Definitive Chemoradiation for Patients with Locally Advanced Esophageal and Gastroesophageal Adenocarcinoma Who Are Not Candidates for Surgery

NRG Oncology

Ku, Geoffrey Yuyat

(646) 888-4588


Phase I/II – 10313

A Phase IB and Randomized Open-Label Phase II Study of M6620 in Combination with Carboplatin/Gemcitabine/Avelumab in Patients with Chemotherapy-Naive Advanced Non-Small Cell Lung Cancer of Squamous Cell Histology

University of Pittsburgh Cancer Institute LAO

Villaruz, Liza C.

(412) 648-6577


Phase II – 10300

BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 1 (BLAST MRD AML-1): A Randomized Phase 2 Study of the Anti-PD-1 Antibody Pembrolizumab in Combination with Conventional Intensive Chemotherapy as Frontline Therapy in Patients with Acute Myeloid Leukemia

Yale University Cancer Center LAO

Zeidan, Amer M.

(203) 737-2572


Phase II – APEC1621M

NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice)- Phase 2 Subprotocol of Tipifarnib in Patients with Tumors Harboring HRAS Genomic Alterations

Children’s Oncology Group

Pratilas, Christine Anne

(443) 287-8623


Phase II – EA5191

A Randomized Phase II Trial of Cabozantinib and Cabozantinib Plus Nivolumab Versus Standard Chemotherapy in Patients with Previously Treated Non-Squamous NSCLC

ECOG-ACRIN Cancer Research Group

Neal, Joel William

(650) 725-3081


Phase II – TRC-10446

Tocilizumab in Hospitalized Cancer Patients with Coronavirus 2019 (SARS-CoV-2) and Severe Complications of Coronavirus Disease 19 (COVID-19)

National Cancer Institute

Little, Richard Fowler

(240) 276-6560


Phase III – A081801

Integration of Immunotherapy Into Adjuvant Therapy for Resected NSCLC: ALCHEMIST Chemo-IO

Alliance for Clinical Trials in Oncology

Sands, Jacob M.

(671) 632-6049


Phase III – NRG-CC005

FORTE (Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps)

NRG Oncology

Schoen, Robert E.

(412) 648-9825


Phase III – S1925

Randomized, Phase III Study of Early Intervention with Venetoclax and Obinutuzumab Versus Delayed Therapy with Venetoclax and Obinutuzumab in Newly Diagnosed Asymptomatic High-Risk Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): EVOLVE CLL/SLL Study

SWOG

Stephens, Deborah Marie

(801) 587-4354


Phase III – WF-1901

Internet-delivered Management of Pain Among Cancer Treatment Survivors (IMPACTS)

Wake Forest NCORP Research Base

Penzien, Donald B.

(336) 716-4382


Phase Other – NCICOVID

NCI COVID-19 in Cancer Patients Study (NCCAPS): A Longitudinal Natural History Study

National Cancer Institute

Korde, Larissa A.

(240) 276-6077

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