G1 Therapeutics and AstraZeneca enter clinical trials collaboration in NSCLC

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G1 Therapeutics Inc. and AstraZeneca announced a collaboration to evaluate AstraZeneca’s epidermal growth factor receptor tyrosine kinase inhibitor Tagrisso (osimertinib) in combination with G1’s oral CDK4/6 inhibitor G1T38 for the treatment of EGFR mutation-positive non-small cell lung cancer.

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Twenty years ago, the discovery of epidermal growth factor receptor mutations as drivers of tumorigenesis and viable targets for therapeutic intervention marked the beginning of a new era in lung cancer diagnosis and treatment. Since then, the field has made remarkable progress towards developing more effective targeted treatments and immunotherapies that have significantly improved patient outcomes and survival.

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