The Cancer Letter

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Drugs & Targets

Novartis and MEI Pharma Receive Breakthrough Therapy Designations

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NOVARTIS said FDA has granted Breakthrough Therapy designation to LEE011 (ribociclib), in combination with letrozole, for the treatment of hormone receptor positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced or metastatic breast cancer. LEE011 is a selective cyclin dependent kinase (CDK4/6) inhibitor.

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