Polaris Group’s lead product candidate, ADI-PEG 20 receives US and EU orphan designations

Polaris Group’s lead product candidate, ADI-PEG 20 (pegylated arginine deiminase), received orphan drug designations for the treatment of malignant pleural mesothelioma in the U.S. and the European Union.

Having completed a successful randomized phase II trial in argininosuccinate synthetase -deficient MPM patients with ADI-PEG 20 as monotherapy, Polaris is currently conducting a phase 1 trial of ADI-PEG 20 in combination with pemetrexed and cisplatin, the approved first-line treatment for MPM, for the treatment of MPM and non-squamous non-small cell lung carcinoma.

Polaris is also conducting clinical trials on ADI-PEG 20 both as monotherapy and in combination with other agents, for the treatment of several other indications including breast cancer, melanomas, ovarian cancer and hepatocellular carcinoma.

ADI-PEG 20 is designed to deplete the external supply of arginine, which causes arginine-dependent cancer cells to die while leaving the patient’s normal cells unharmed.

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Polaris Group’s lead product candidate, ADI-PEG 20 receives US and EU orphan designations

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Polaris Group’s lead product candidate, ADI-PEG 20 receives US and EU orphan designations

YOU MAY BE INTERESTED IN

Early-onset colorectal cancer is behaving like a new, biologically distinct disease, researchers noteOne woman’s pregnancy shows how this distinction matters

Maura Gillison, who identified the role of HPV in head and neck cancer, changing the standard of care, dies at 61

Is it time to re-assess the practice and practicality of screening colonoscopy?Modeling data in ACS guideline support greater use of noninvasive tests to ease system strain, save lives

More than 50 million Americans remain unscreened for colon cancerNew guidelines offer another option

AACR urges OMB to retract proposed rule on federally funded research

CDC updates ACIP charter

Never miss an issue!

Login

Early-onset colorectal cancer is behaving like a new, biologically distinct disease, researchers note
One woman’s pregnancy shows how this distinction matters

Is it time to re-assess the practice and practicality of screening colonoscopy?
Modeling data in ACS guideline support greater use of noninvasive tests to ease system strain, save lives

More than 50 million Americans remain unscreened for colon cancer
New guidelines offer another option