Ronald A. DePinho
Ronald A. DePinho

Professor, past president, Harry Graves Burkhart III Distinguished University Chair, Department of Cancer Biology, MD Anderson Cancer Center

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Guest Editorial
The year was 1998, location, Italian Alps. Jim and I were attending an intimate Pezcoller meeting organized by David Livingston. At that meeting, Jim presented something I had never seen in the entirety of my career—the eradication of cancer in mice following treatment with an antibody designed to inhibit a T cell checkpoint mechanism.