Novartis reports positive results from phase III trial of Kisqali for advanced or metastatic breast cancer

Phase III persevERA study of giredestrant combination in ER-positive advanced breast cancer does not meet primary objective

The phase III persevERA Breast Cancer study, evaluating investigational giredestrant in combination with palbociclib for people with oestrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer, did not meet its primary objective of a statistically significant improvement in progression-free survival in the intent-to-treat population versus letrozole plus palbociclib, but a numerical improvement was observed.

March 13, 2026

Vol.52 No.10

Cancer Policy

Mt. Sinai forms committee to probe Epstein links to breast center founder Eva Dubin, other faculty members

Mount Sinai hospital has formed a committee to investigate the ties between Jeffrey Epstein and Eva Dubin a leading doctor at the hospital and founder of the Dubin Breast Center at the Tisch Cancer Institute whose name is featured prominently in the Epstein files.

March 06, 2026

Vol.52 No.09

By Claire Marie Porter and Sara Willa Ernst

Clinical Roundup

TNBC can become resistant to therapy in more than one way, Baylor study finds

About 50% of triple-negative breast cancer patients develop resistance to therapy. When resistance arises, tumors are more likely to come back after the original treatment, significantly reducing the chances of survival.

March 06, 2026

Vol.52 No.09

Clinical Roundup

Exercise during chemotherapy for breast cancer improves quality of life, Sylvester-led study finds

For many women with breast cancer, the treatment that saves their lives also brings fatigue that clings like a heavy coat, loss of muscle mass that turns everyday tasks into obstacles and emotional strain that lingers long after each infusion ends. It’s a season defined not just by survival, but by how well patients are able to live through it.

February 27, 2026

Vol.52 No.08

In Brief

Indiana University receives $5M grant to expand breast cancer diagnosis, care in Kenya

The Indiana University Melvin and Bren Simon Comprehensive Cancer Center has been awarded a $5 million grant from the Pfizer Foundation to expand access to timely breast cancer diagnosis, treatment, and care in Kenya.

February 20, 2026

Vol.52 No.07

Clinical Roundup

Exposure to pathogenic bacteria significantly increased SMOX activity, leading growth and metastasis of breast cancer, JHU-led study finds

Researchers at the Johns Hopkins Kimmel Cancer Center have discovered how certain pathogenic bacteria in gut and breast tissue can promote breast cancer development and progression by hijacking a key metabolic enzyme known as spermine oxidase.

February 20, 2026

Vol.52 No.07

Novartis reports positive results from phase III trial of Kisqali for advanced or metastatic breast cancer

YOU MAY BE INTERESTED IN

Phase III persevERA study of giredestrant combination in ER-positive advanced breast cancer does not meet primary objective

Mt. Sinai forms committee to probe Epstein links to breast center founder Eva Dubin, other faculty members

TNBC can become resistant to therapy in more than one way, Baylor study finds

Exercise during chemotherapy for breast cancer improves quality of life, Sylvester-led study finds

Indiana University receives $5M grant to expand breast cancer diagnosis, care in Kenya

Exposure to pathogenic bacteria significantly increased SMOX activity, leading growth and metastasis of breast cancer, JHU-led study finds

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