Vyxeos Injection Improves Overall Survival in Phase III Acute Myeloid Leukemia Trial

All-oral regimen of decitabine-cedazuridine + venetoclax yields 47% complete response rate, ASCERTAIN-V phase I/II clinical trial finds

The ASCERTAIN-V phase I/II clinical trial, which evaluated the first all-oral regimen of decitabine-cedazuridine plus venetoclax in patients with newly diagnosed acute myeloid leukemia who are ineligible for intensive induction chemotherapy, demonstrated favorable response rates and survival with expected myelosuppressive effects.

June 18, 2026

Vol.52 No.24

Clinical Roundup

Jaypirca + venetolax + rituximab reduced the risk of disease progression or death by 45% in r/r CLL/SLL, phase III BRUIN CLL-322 trial finds

Jaypirca (pirtobrutinib), a non-covalent Bruton tyrosine kinase inhibitor, plus a two-year venetoclax and rituximab regimen versus venetoclax and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma reduced the risk of disease progression or death by 45% (HR=0.55 [95% CI, 0.40-0.75]; p=0.0001), according to the results of the phase III BRUIN CLL-322 trial. The study met its primary endpoint of independent review committee-assessed progression-free survival.

June 18, 2026

Vol.52 No.24

Clinical Roundup

Vispa-cel well-tolerated in second-line large B cell lymphoma, ANTLER phase I study finds

Vispa-cel, an off-the-shelf CD19-targeted CAR-T cell therapy, produced durable long-term responses in patients enrolled in the ANTLER phase I clinical trial for relapsed or refractory B cell non-Hodgkin lymphoma, with the potential to bring the benefit of cell therapy to patients who lack curative options.

June 18, 2026

Vol.52 No.24

Clinical Roundup

Tafasitamab + lenalidomide and R-CHOP improves PFS, phase III frontMIND trial finds

The phase III frontMIND trial evaluating the efficacy and safety of tafasitamab (Monjuvi/Minjuvi), a humanized Fc-modified cytolytic CD19-targeting monoclonal antibody, and lenalidomide added to R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone; Tafa-Len-R-CHOP) versus R-CHOP alone as a first-line treatment for adults with previously untreated diffuse large B-cell lymphoma or high-grade B-cell lymphoma, has produced positive results.

June 12, 2026

Vol.52 No.23

Drugs & Targets

FDA grants Fast Track designation for STX-0712 for r/r CMML

FDA has granted Fast Track designation to STX-0712, an investigational therapy in development for the treatment of relapsed or refractory chronic myelomonocytic leukemia.

May 29, 2026

Vol.52 No.21

Clinical Roundup

“Forever chemicals” may be linked to childhood leukemia, UC Irvine study finds

Early exposure to PFAS, a group of widely used compounds known as “forever chemicals,” was associated with a higher risk of acute lymphoblastic leukemia, the most common childhood cancer, according to researchers at the University of California, Irvine Joe C. Wen School of Population & Public Health.

May 01, 2026

Vol.52 No.17

Vyxeos Injection Improves Overall Survival in Phase III Acute Myeloid Leukemia Trial

YOU MAY BE INTERESTED IN

All-oral regimen of decitabine-cedazuridine + venetoclax yields 47% complete response rate, ASCERTAIN-V phase I/II clinical trial finds

Jaypirca + venetolax + rituximab reduced the risk of disease progression or death by 45% in r/r CLL/SLL, phase III BRUIN CLL-322 trial finds

Vispa-cel well-tolerated in second-line large B cell lymphoma, ANTLER phase I study finds

Tafasitamab + lenalidomide and R-CHOP improves PFS, phase III frontMIND trial finds

FDA grants Fast Track designation for STX-0712 for r/r CMML

“Forever chemicals” may be linked to childhood leukemia, UC Irvine study finds

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