Van Andel scientists develop improved single-cell DNA methylation technique

Epigenetic research reveals a potential treatment for CRC and other solid tumors

A little-known mouse protein disrupts cancer-causing chemical changes to genes associated with human colorectal cancer cells and potentially could be used to treat solid tumors, according to a new study from researchers at the Johns Hopkins Kimmel Cancer Center and the Chinese Academy of Sciences.

January 17, 2025

Vol.51 No.02

Tumors are able to form with no DNA mutations, fly study shows

Tumors are able to form without any DNA mutations, according to a recent proof-of-principle study performed in flies. Epigenetic changes alone—even temporary alterations—induced permanent cancer cell fate.

Upregulating TERT gene expression reverses multiple hallmarks of aging

Researchers at MD Anderson Cancer Center have demonstrated that therapeutically restoring ‘youthful’ levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models.

June 28, 2024

Vol.50 No.26

Clinical Roundup

T-cell aging not limited by organismal age, allowing healthy cells to proliferate in perpetuity

While most cell types experience a functional decline after years of proliferation and replication, T cells can proliferate seemingly indefinitely and without detriment.

June 14, 2024

Vol.50 No.24

Clinical Roundup

Epigenomic platform may predict NSCLC immunotherapy response using liquid biopsies

Data published in The Journal for ImmunoTherapy of Cancer show ClearNote Health’s epigenomic platform may provide a novel tissue-free, liquid biopsy-based approach for prediction and monitoring of immunotherapy response for non-small cell lung cancer patients.

January 19, 2024

Vol.50 No.03

Letter To The Editor

The field of population epigenetics is failing on rigor and reproducibility

To the editor, I was not booed off the stage. Rather, the response was incredibly enthusiastic. After my session people lined up for over 45 minutes to talk to me. Many thanked me for publicizing this issue, indicating that the problems with the Illumina platform have been apparent to many, but no one else was...

December 08, 2023

Vol.49 No.45

Van Andel scientists develop improved single-cell DNA methylation technique

YOU MAY BE INTERESTED IN

Epigenetic research reveals a potential treatment for CRC and other solid tumors

Tumors are able to form with no DNA mutations, fly study shows

Upregulating TERT gene expression reverses multiple hallmarks of aging

T-cell aging not limited by organismal age, allowing healthy cells to proliferate in perpetuity

Epigenomic platform may predict NSCLC immunotherapy response using liquid biopsies

The field of population epigenetics is failing on rigor and reproducibility

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