Study data from MAIA Biotechnology, Inc. showed that THIO (6-thio-dG or 6-thio-2’-deoxyguanosine), a first-in-class investigational telomere-targeting agent, demonstrates potent anticancer activity in diffuse intrinsic pontine glioma, one of the most aggressive tumors affecting the central nervous system in children.
Researchers at Baylor College of Medicine and collaborating institutions investigated for the first time in cancer the association between two sources of genetic variation: germline or inherited structural variation, which refers to large differences in the DNA sequence, and DNA methylation, which is when genes are turned on or off without altering the DNA code.
