Sylvester researchers target treatment-resistant prostate cancer with oral chemo in preclinical study

Beyond the lab: Engineering collaboration in modern cancer research

Cancer research increasingly demands environments that mirror the biology it seeks to understand: Complex, adaptive and deeply interconnected. At Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, collaboration is not treated as an optional cultural trait but as a structural requirement.

March 27, 2026

Vol.52 No.12

Clinical Roundup

Talzenna + Xtandi significantly improves radiographic PFS in metastatic prostate cancer

Pfizer announced positive topline results from the phase III TALAPRO-3 study of Talzenna (talazoparib), an oral poly ADP-ribose polymerase inhibitor, in combination with Xtandi (enzalutamide), an androgen receptor pathway inhibitor, in people with homologous recombination repair gene-mutated metastatic castration-sensitive prostate cancer, also known as metastatic hormone-sensitive prostate cancer.

March 27, 2026

Vol.52 No.12

Clinical Roundup

Researchers “turbocharge” immune cells to attack prostate cancer

A team of researchers engineered a new class of “turbocharged” T cells that may be stronger, longer-lasting, and more precise at killing prostate cancer cells. The approach represents a step toward developing safer, more effective T-cell therapies for prostate cancer and could potentially be adapted to treat a wide range of other tumors.

March 27, 2026

Vol.52 No.12

Clinical Roundup

Hormone therapy may not benefit most men receiving radiotherapy after prostate surgery, UCLA-led study finds

A study led by UCLA Health Jonsson Comprehensive Cancer Center investigators suggests that adding hormone therapy to post-operative radiotherapy may provide little survival benefit for most men with prostate cancer, especially for those with very low PSA levels before treatment.

March 06, 2026

Vol.52 No.09

Clinical Roundup

Adjuvant immunotherapy + hormone therapy may counteract immune-suppression in early-stage prostate cancer, Mayo-led study finds

Pairing a next-generation immunotherapy with standard hormone therapy before surgery may help overcome a long-standing barrier in early-stage prostate cancer treatment, according to a Mayo Clinic-led study.

February 27, 2026

Vol.52 No.08

Clinical Roundup

“Lock-and-key” chemistry platform may keep therapeutic drugs inactive until they reach a tumor, Syracuse-led study finds

Many therapeutic molecules used in cancer treatments are highly toxic, often harming healthy tissues and causing significant side effects. This creates a critical need for strategies that localize their toxic activity to tumors. What if cancer drugs could stay dormant until they reach cancer cells? A study by Syracuse University researchers demonstrates a promising chemistry-based strategy that could do just that.

February 27, 2026

Vol.52 No.08

Sylvester researchers target treatment-resistant prostate cancer with oral chemo in preclinical study

YOU MAY BE INTERESTED IN

Beyond the lab: Engineering collaboration in modern cancer research

Talzenna + Xtandi significantly improves radiographic PFS in metastatic prostate cancer

Researchers “turbocharge” immune cells to attack prostate cancer

Hormone therapy may not benefit most men receiving radiotherapy after prostate surgery, UCLA-led study finds

Adjuvant immunotherapy + hormone therapy may counteract immune-suppression in early-stage prostate cancer, Mayo-led study finds

“Lock-and-key” chemistry platform may keep therapeutic drugs inactive until they reach a tumor, Syracuse-led study finds

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