Approximately one-third of patients with non-small-cell lung cancer who were treated with the targeted therapy Lumakras (sotorasib) survived for at least two years after enrolling in a large clinical trial that evaluated the drug—significantly longer than what can be expected from patients treated with standard chemotherapy.
FDA has accepted a New Drug Application for zipalertinib for the treatment of patients with locally advanced or metastatic non-small cell lung cancer with epidermal growth factor receptor exon 20 insertion mutations whose disease has progressed on or after platinum-based chemotherapy, with or without amivantamab. The Prescription Drug User Fee Act target action date is Feb. 27, 2027.
