City of Hope’s investigational COVID-19 vaccine generates robust immune response

Scaling excellence: How City of Hope is transforming cancer care delivery

The landscape of cancer care in America faces critical challenges: geographic disparities in access, socioeconomic barriers to advanced treatments and the increasing complexity of precision medicine that outpaces individual providers’ ability to stay current. At City of Hope, we are addressing these systemic issues through a bold expansion that brings world-class cancer care and research closer to where patients live.

July 03, 2025

Vol.51 No.26

By Alan H. Bryce and Walter M. Stadler

Clinical Roundup

City of Hope launches AI tool to reduce burden of cancer care

City of Hope is using generative artificial intelligence to create operational efficiency, enable AI-driven patient personalization, improve access to clinical trials, and empower breakthrough research.

June 27, 2025

Vol.51 No.25

From “undruggable” target to clinical potential: The journey of AOH1996

When I first proposed targeting PCNA (proliferating cell nuclear antigen) as a therapeutic approach, the response I got was: “No one will ever make a drug against PCNA. It’s undruggable.” The protein lacks enzymatic activity, has a disordered region, and binds to over 200 other proteins within the cell. From a traditional drug development perspective, these characteristics made PCNA an impossible target.

City of Hope awarded $23.7M from ARPA-H for biomarker mapping

City of Hope has been awarded an up to $23.7 million contract from the Advanced Research Projects Agency for Health within the U.S. Department of Health and Human Services. The grant will help City of Hope create a biomap of tumor changes that cause immunotherapy resistance in advanced or metastatic non-small cell lung cancer.

June 20, 2025

Vol.51 No.24

Insights from ASCO 2025: Real-world evidence drives clinical decision-making

City of Hope researchers presented compelling real-world evidence and novel combination therapies at the 2025 ASCO Annual Meeting, with findings that could reshape treatment approaches for breast, colorectal, renal, and prostate cancers.

Young women are now diagnosed with cancer at twice the rate of young men
The face of cancer is changing at a time when research is plagued by existential threats

For more than a year before her stage 4 lung cancer was found, 35-year-old Alisa Secaida, a never-smoker and a physically active Southern Californian, had been experiencing a persistent cough and, increasingly, fatigue.

June 06, 2025

Vol.51 No.22

By Claire Marie Porter

City of Hope’s investigational COVID-19 vaccine generates robust immune response

YOU MAY BE INTERESTED IN

Scaling excellence: How City of Hope is transforming cancer care delivery

City of Hope launches AI tool to reduce burden of cancer care

From “undruggable” target to clinical potential: The journey of AOH1996

City of Hope awarded $23.7M from ARPA-H for biomarker mapping

Insights from ASCO 2025: Real-world evidence drives clinical decision-making

Young women are now diagnosed with cancer at twice the rate of young men
The face of cancer is changing at a time when research is plagued by existential threats

Renew today!

Subscriber content

Never miss an issue!

Login

City of Hope’s investigational COVID-19 vaccine generates robust immune response

YOU MAY BE INTERESTED IN

Scaling excellence: How City of Hope is transforming cancer care delivery

City of Hope launches AI tool to reduce burden of cancer care

From “undruggable” target to clinical potential: The journey of AOH1996

City of Hope awarded $23.7M from ARPA-H for biomarker mapping

Insights from ASCO 2025: Real-world evidence drives clinical decision-making

Young women are now diagnosed with cancer at twice the rate of young menThe face of cancer is changing at a time when research is plagued by existential threats

Never miss an issue!

Login

Young women are now diagnosed with cancer at twice the rate of young men
The face of cancer is changing at a time when research is plagued by existential threats