publication date: Jul. 2, 2020

In Brief

Yale Cancer Center receives $2.8M NCI cancer systems immunology grant

Yale Cancer Center researchers received a $2.8 million grant from NCI to evaluate and model cytokine signaling related to immunotherapy for cancer.

The scientists and their laboratories will collaborate to determine how cells within the tumor microenvironment utilize cytokine signaling and will generate computational models to explain this behavior.

Kathryn Miller-Jensen, associate professor of biomedical engineering and molecular, cellular, and developmental biology, along with Marcus Bosenberg, interim director of the Yale Center for Immuno-Oncology and professor of dermatology, pathology, and immunobiology, will lead the research.

“This grant reflects the type of multidisciplinary research that we encourage in the YCIO, combining a broad range of required skills from several laboratories,” Bosenberg said in a statement.

The research team also includes Harriet Kluger, professor of medicine (medical oncology) and co-director of the Yale SPORE in Skin Cancer, and Susan Kaech, professor and director of the NOMIS Center for Immunobiology and Microbial Pathogenesis at the Salk Institute for Biological Studies.

In addition to research funding, the award will establish Miller-Jensen and Bosenberg as members of the Cancer Systems Biology Consortium, a science network founded by NCI devoted to enhancing the role of systems biology approaches to cancer research.

The work will take advantage of recent advances that enable measurements of gene expression and cytokine levels in individual cells in tumors. Using computational algorithms, the team will construct networks of cytokine communication between immune cells in melanoma tumors.

By tracking how these networks change in tumors that are responsive or unresponsive to immunotherapy, novel targets will be identified and evaluated further.

“High-throughput single- cell data … Continue reading Yale Cancer Center receives $2.8M NCI cancer systems immunology grant

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