publication date: Jul. 26, 2019

Conversation with The Cancer Letter

Zhang: St. Jude Cloud, world’s largest whole genome repository, is ready to test federated model

00150879-014, 08-26-11, staff - location portraits, office, computer monitors, sequencing, Human Genome Project, Computational Biology, Jinghui (Zhang) Baker PhD,

Jinghui Zhang

St. Jude Endowed Chair in Bioinformatics,

Chair, Department of Computational Biology

St. Jude Children’s Research Hospital 


Researchers looking to aggregate and harmonize genomic data—a critical undertaking that would empower translational research in pediatric oncology—will face technical complexities that exceed the challenges of enabling interoperability between electronic health record systems, said Jinghui Zhang, the St. Jude Endowed Chair in Bioinformatics and chair of the Department of Computational Biology at St. Jude Children’s Research Hospital.

“We can use ‘blood test’ as an analogy to illustrate the difference between text mining of EHR record versus genomic data mining,” Zhang said. “Genomic data, like a ‘blood sample,’ cannot be used directly for text mining. After performing computational analysis using the genomic analysis algorithms, which is analogous to ordering a blood test, results will be generated, similar to getting a blood test report, on which text mining can be performed.

“Therefore, accessibility to raw genomic data is important, as we can perform multiple ‘tests’ to derive different types of ‘reports.’”

According to Zhang, St. Jude Cloud—St. Jude Children’s Research Hospital’s venture into oncology big data—will be focusing its … Continue reading Zhang: St. Jude Cloud, world’s largest whole genome repository, is ready to test federated model

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