publication date: Dec. 7, 2018

Clinical Roundup Kite announces two-year data for Yescarta in patients with refractory large B-cell lymphoma

Kite, a Gilead company, announced two-year efficacy and safety data from the pivotal ZUMA-1 trial of Yescarta (axicabtagene ciloleucel) in patients with refractory large B-cell lymphoma. With a minimum follow-up of two years after a single infusion of Yescarta (median follow up of 27.1 months), 39 percent of patients were in an ongoing response.

This updated analysis with at least 24 months of follow-up was presented at ASH and simultaneously published in The Lancet Oncology.

In October 2017, Yescarta became the first chimeric antigen receptor T cell therapy to be approved by the FDA for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma not otherwise specified, primary mediastinal large B-cell lymphoma, high grade B-cell lymphoma and DLBCL arising from follicular lymphoma.

Yescarta is not indicated for the treatment of patients with primary central nervous system lymphoma. The U.S. Prescribing Information for Yescarta contains a Boxed Warning regarding the risk of cytokine release syndrome and neurologic toxicities.

At two years, the best objective response via investigator assessment (n=101) showed an overall response rate of 83 percent, with 58 percent of patients having achieved a complete response. … Continue reading Kite announces two-year data for Yescarta in patients with refractory large B-cell lymphoma

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