publication date: Apr. 27, 2018

In Brief

John Sampson to lead Duke’s physician practice of over 1,500 members

John Sampson was elected president of the Private Diagnostic Clinic, the physician practice of Duke Health, with 1,650 members practicing in Duke hospitals and more than 100 clinics in North Carolina.

Sampson will continue to serve as chair of the Duke Department of Neurosurgery. The PDC is one of the first and the largest academic multi-specialty group practices in the U.S., with 1.7 million patient visits in FY18 and $850 million in total revenue.

In addition to patient care, PDC members conduct research and serve as faculty in the Duke University School of Medicine. The PDC collaborates with other entities within the Duke University Health System to expand opportunities and advance Duke’s clinical, research, and academic missions.

In this role, Sampson will provide strategic direction and oversight of the financial and management aspects of the physician organization. This includes implementing initiatives to best position the PDC for continued growth and success, and leading, on behalf of PDC members, the due diligence and negotiations of the potential integration of the PDC and Duke University Health System.

Sampson is the Robert H. and Gloria Wilkins Distinguished Professor and co-leader of the Duke Cancer Institute Neuro-Oncology program. He is a recognized leader in the surgical resection and experimental treatment of complex brain tumors.

He currently focuses his clinical practice on treating patients with benign and malignant brain tumors and divides his time between his clinical practice and an active research laboratory investigating new modalities of direct brain tumor infusion and immunotherapy.

 

Carl Schmidt joins WVU Cancer Institute

Carl Schmidt, a surgical oncologist specializing in cancers of the liver, pancreas, and stomach, will join the West Virginia University Cancer Institute in July.

Schmidt will serve chief of surgical oncology and surgeon in chief of the WVU Cancer Institute. He plans to grow the program’s capacity to serve a larger number of patients and offer more innovative surgeries through fostering relationships across the state.

Schmidt comes to WVU from the Ohio State University College of Medicine Wexner Medical Center, where he served as associate professor of surgery. At Ohio State, he also served as vice chair of quality and patient safety and program director for surgical oncology fellowships.

Schmidt’s scholarly work focuses on outcomes for patients with gastrointestinal cancers and quality of care for cancer patients.

 

NCCN publishes translations of guidelines for patients

The National Comprehensive Cancer Network has published a newly-translated Italian version of the NCCN Guidelines for Patients for stomach cancer, funded by the NCCN Foundation thanks to No Stomach for Cancer.

Over the past year, the NCCN Foundation also worked with the Kidney Cancer Association to translate patient guidelines for kidney cancer into Chinese, Czech, German, and Spanish.

The guidelines are available free-of-charge at NCCN’s website or via through their app. Print copies of the NCCN Guidelines for Patients are available on Amazon.com for a nominal fee.

In 2017 alone, the NCCN Guidelines for Patients were viewed more than eight million times by nearly 400,000 individuals, worldwide. The library currently contains 39 different guidelines, including breast, colon, lung, and prostate cancers.

 

Melanoma Research Alliance announces $11.8 Million in 28 research grants

The Melanoma Research Alliance has announced funding for 28 research grants totaling $11.8 million.

The awards will fund researchers at 23 institutions from across the United States, Australia, and Belgium to accelerate research and advance the prevention, diagnosis and treatment of melanoma.

This year’s grant awards will support 13 Team Science Awards and 15 Young Investigator Awards. Together, these awards represent the single largest grant year ever by the Melanoma Research Alliance and brings the total invested by the organization to over $100 million.

These 28 research projects will accelerate research addressing critical issues in melanoma, including identifying novel drug targets, treatments and biomarkers, as well as studies aimed at preventing melanoma or improving methods of early detection.

Several research projects will provide critical advancements in the understanding of rare and difficult-to-treat melanoma subtypes. Six awards will examine new therapeutic interventions to determine how specific genetic alterations contribute to the development and progression to acral lentiginous melanoma.

MRA’s 2018 grants are made possible through the significant contributions of individuals, families, institutions and corporate allies. Donors and partners providing financial support for 75% or more of an award are listed below within the award naming.


2018 Awards

Team Science Awards

Targeting BAP1-dependent alterations in metastatic uveal melanoma

The Helman Family-MRA Team Science Award, 2018-2021

  • Andrew Aplin, Thomas Jefferson University

  • Emily Bernstein, Icahn School of Medicine at Mount Sinai

  • J. William Harbour, Sylvester Comprehensive Cancer Center/University of Miami Health Systems

  • Young Investigator: Marlana Orloff, Thomas Jefferson University

Diet, mental health, and the microbiome in response to immunotherapy

MRA Team Science Award, collaboratively funded by University of Texas MD Anderson Cancer Center, 2018-2021

  • Lorenzo Cohen, University of Texas MD Anderson Cancer Center

  • Jennifer Wargo, University of Texas MD Anderson Cancer Center

  • Young Investigator: Jennifer McQuade, University of Texas MD Anderson Cancer Center

Autophagy in the tumor microenvironment as a target for drug development

The Anna-Maria and Stephen Kellen Foundation-MRA Team Science Award, 2018-2021

  • Hilary Coller, University of California, Los Angeles

  • Beatrice Knudsen, Cedars-Sinai Medical Center

  • Lili Yang, University of California, Los Angeles

  • Young Investigator: Claudio Scafoglio, University of California, Los Angeles

Telomere crisis in acral melanoma: Diagnostic and prognostic potentials

The Black Family-MRA Team Science Award, 2018-2021

  • Titia de Lange, The Rockefeller University

  • Marcin Imielinski, Joan & Sanford I. Weill Medical College of Cornell University

  • Young Investigator: John Maciejowski, Memorial Sloan Kettering Cancer Center

Commensal microbiota and anti-PD-1 efficacy

MRA Team Science Award, collaboratively funded by The University of Chicago, 2018-2021

  • Thomas Gajewski, The University of Chicago

  • Jason Luke, The University of Chicago

  • Cathryn Nagler, The University of Chicago

  • Young Investigator: Riyue Bao, The University of Chicago

Patient focused therapy for acral melanoma

The Sokoloff Family-MRA Team Science Award, with collaborative funding from Memorial Sloan Kettering Cancer Center, 2018-2021

  • Ruth Halaban, Yale University

  • Charlotte Ariyan, Memorial Sloan Kettering Cancer Center

  • Alfred Bothwell, Yale University

  • Jian Cao, Yale University

  • Neal Rosen, Memorial Sloan Kettering Cancer Center

  • Richard White, Memorial Sloan Kettering Cancer Center

  • Jedd Wolchok, Memorial Sloan Kettering Cancer Center

  • Qin Yan, Yale University

  • Young Investigator: Gauri Panse, Yale University

Identifying genetic dependencies in rare forms of melanoma

MRA Team Science Award, 2018-2021

  • Nicholas Hayward, Queensland Institute of Medical Research

  • Francisca Vazquez, Broad Institute

  • Young Investigator: Ken Dutton-Regester, Queensland Institute of Medical Research

Prognostic and functional role of altered circular RNAs in melanoma

Leveraged Finance Fights Melanoma-MRA Team Science Award, 2018-2021

  • Eva Hernando, New York University School of Medicine

  • Ernesto Guccione, Icahn School of Medicine at Mount Sinai

  • Edward and Julie Minskoff – Young Investigator: Melissa Wilson, New York University School of Medicine

Next-generation neoantigen-targeting peptide vaccines for melanoma patients

BJ’s Wholesale Club-MRA Team Science Award, 2018-2021

  • Patrick Ott, Dana-Farber Cancer Institute

  • Bradley Pentelute, Massachusetts Institute of Technology

  • Catherine Wu, Dana-Farber Cancer Institute

  • Young Investigator: Osama Rahma, Dana-Farber Cancer Institute

Regulating telomerase & telomere homeostasis in acral melanoma development

MRA Team Science Award, collaboratively funded by the research institutions, 2018-2021

  • Gavin Robertson, The Pennsylvania State University College of Medicine

  • Jiyue Zhu, Washington State University

  • Young Investigator: De Cheng, Washington State University

  • Young Investigator: Shobhan Gaddameedhi, Washington State University

  • Young Investigator: Raghavendra Gowda, The Pennsylvania State University College of Medicine

Defining and targeting driver events in acral melanoma

U.S. Trust-MRA Team Science Award, 2018-2021

  • Keiran Smalley, H. Lee Moffitt Cancer Center & Research Institute

  • Yian Chen, H. Lee Moffitt Cancer Center & Research Institute

  • John Koomen, H. Lee Moffitt Cancer Center & Research Institute

  • Jane Messina, H. Lee Moffitt Cancer Center & Research Institute

  • Jamie Teer, H. Lee Moffitt Cancer Center & Research Institute

  • Young Investigator, Florian Karreth, H. Lee Moffitt Cancer Center & Research Institute

Directing adaptive immune responses to non-polymorphic MHCs in melanoma

MRA Team Science Award, collaboratively funded by Massachusetts Institute of Technology, 2018-2021

  • Forest White, Massachusetts Institute of Technology-Koch Institute for Integrative Cancer Research

  • Dane Wittrup, Massachusetts Institute of Technology

  • Young Investigator: Michael Birnbaum, Massachusetts Institute of Technology-Koch Institute for Integrative Cancer Research

  • Young Investigator: Stefani Spranger, Massachusetts Institute of Technology-Koch Institute for Integrative Cancer Research

DAMPening immunotherapy adverse events in melanoma

MRA Team Science Award, collaboratively funded by the research institutions, 2018-2021

  • Pan Zheng, University of Maryland, Baltimore

  • Yang Liu, University of Maryland, Baltimore

  • Young Investigator: Siwen Hu-Lieskovan, The University of California, Los Angele


Young Investigator Awards

Molecular and immune profiling of acral melanoma from various ethnicities

MRA Young Investigator Award, collaboratively funded by University of Texas MD Anderson Cancer Center, 2018-2021

  • Phyu Aung, University of Texas MD Anderson Cancer Center

Building a predictive framework for vaccine design against melanoma

Elliott and Ruth Sigal-MRA Young Investigator Award, 2018-2021

  • Nicolas Chevrier, The University of Chicago

Manipulating cellular metabolism to promote cancer immunity in melanoma

The Robbins Family-MRA Young Investigator Award, 2018-2021

  • Ku-Lung Hsu, The University of Virginia

Investigating the mechanistic basis for tumor immunogenicity in melanoma

The Sokoloff Family-MRA Young Investigator Award, 2018-2021

  • Nikhil Joshi, Yale University

LncRNAs as modulators of protein synthesis rewiring in melanoma

Amanda and Jonathan Eilian-MRA Young Investigator Award, 2018-2021

  • Eleonora Leucci, Katholieke Universiteit Leuven

Primary anogenital melanoma: Comprehensive molecular and immune analysis

MRA Young Investigator Award, collaboratively funded by University of Texas MD Anderson Cancer Center, 2018-2021

  • Priyadharsini Nagarajan, University of Texas MD Anderson Cancer Center

Isoform-specific targeting of the PI3Ks to overcome cancer immunoresistance

MRA Young Investigator Award, collaboratively funded by University of Texas MD Anderson Cancer Center, 2018-2021

  • Weiyi Peng, University of Texas MD Anderson Cancer Center

Dependence of melanoma metastasis on AMPK-mediated metabolic switch

Ellen and Gary Davis Foundation-MRA Young Investigator Award, collaboratively funded by Joan & Sanford I. Weill Medical College of Cornell University, 2018-2021

  • Elena Piskounova, Joan & Sanford I. Weill Medical College of Cornell University

The genomic landscape of individual melanocytes from human skin

Tara Miller Melanoma Foundation-MRA Young Investigator Award, 2018-2021

  • A. Hunter Shain, The University of California, San Francisco

A novel approach for NF1 mutant melanoma sub-classification

MRA Young Investigator Award, 2018-2021

  • Edward Stites, The Salk Institute for Biological Studies

Targeting PSGL-1 inhibitory pathways to promote anti-tumor T cell immunity

The Denise and Michael Kellen Foundation-MRA Young Investigator Award, 2018-2021

  • Roberto Tinoco, Sanford Burnham Prebys Medical Discovery Institute

Pilot study of intervention to reduce sunburns in melanoma survivors

The Wayne Stinchcomb Big Orange Foundation-MRA Young Investigator Award for Women in Scientific Research, 2018-2021

  • Rachel Vogel, The University of Minnesota – Twin Cities

Targeting the JNK-ITCH signaling pathway in melanoma

Mary Jo and Brian Rogers-MRA Young Investigator Award, 2018-2021

  • Lixin Wan, H. Lee Moffitt Cancer Center & Research Institute

Developing advanced non-invasive histology techniques

Brownstein, Hyatt, Farber & Schreck-MRA Young Investigator Award, 2018-2021

  • Jesse Wilson, Colorado State University

Targeting BRAF/NRAS wildtype melanoma with ERBB3 and MEK Inhibition

Julie and Edward J. Minskoff-MRA Young Investigator Award, collaboratively funded by New York University School of Medicine, 2018-2021

  • Melissa Wilson, New York University School of Medicine

Copyright (c) 2018 The Cancer Letter Inc.