publication date: Feb. 9, 2018
In phase III study Tecentriq and Avastin reduced risk of disease worsening/death by 26 percent in advanced kidney cancer
Genentech announced results from the positive phase III IMmotion151 study of Tecentriq (atezolizumab) and Avastin (bevacizumab) as a first-line treatment for advanced or metastatic renal cell carcinoma.
The study met its co-primary endpoint of investigator-assessed progression-free survival in people whose disease expressed the PD-L1 (expression ≥ 1 percent) protein. Those who received Tecentriq plus Avastin had a 26-percent reduced risk of disease worsening or death compared to people treated with sunitinib (median PFS [mPFS]: 11.2 vs. 7.7 months; HR=0.74; 95 percent CI 0.57, 0.96; p=0.02).
Initial observations from the co-primary endpoint of overall survival in the overall study population (intention-to-treat) are still immature. Safety for the Tecentriq and Avastin combination appeared consistent with the known safety profile of the individual medicines and what was previously reported in the phase II IMmotion150 study.
No new safety signals were identified with the combination. The rate of treatment-related grade III-IV adverse events was lower with the Tecentriq and Avastin combination (40 percent) than with sunitinib alone (54 percent) in all treated patients.
Observations of a pre-specified subgroup analysis of the Tecentriq and Avastin combination indicated that, in people whose disease expressed PD-L1, a numerical difference in PFS favoring Tecentriq was seen across all patient risk factor groups (favorable, intermediate and poor) compared to sunitinib.
In addition, a pre-defined analysis of patient-reported outcomes revealed that the combination of Tecentriq and Avastin markedly delayed the time to a worsening of disease symptoms that interfere with day-to-day life compared to sunitinib, (median time to deterioration: 11.3 vs. 4.3 months; HR=0.56; 95 percent CI: 0.46, 0.68) in the ITT population. Due to the study design, pre-defined subgroup analyses and pre-defined … Continue reading In phase III study Tecentriq and Avastin reduced risk of disease worsening/death by 26 percent in advanced kidney cancer
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