publication date: Feb. 27, 2015

PCORI Approves $64 Million For Five 2015 Grant Awards


The Patient-Centered Outcomes Research Institute approved awards totaling more than $64 million to fund five large patient-centered comparative effectiveness research studies concentrating on cancer, back pain and stroke.

These are the first awards made through the institute’s Pragmatic Clinical Studies Initiative, an effort to produce results that can be more quickly taken up in routine clinical practice. The grants range from $7.75 million to $14.5 million each.

The three studies focusing on cancer are detailed below. The other two studies will explore: primary care versus prompt referral to physical therapy combined with cognitive behavioral therapy to see which more effectively prevents acute low back pain from progressing to chronic pain; and also whether a comprehensive package of transitional care and in-home support services is more effective than usual care at improving stroke survivors’ functional abilities and preventing hospital readmissions.

The five studies were selected from proposals submitted to PCORI’s first funding announcement issued last February. PCORI has issued three funding announcements through this initiative to date, seeking proposals that focus on a series of key CER topics identified by PCORI’s advisory panels, the Institute of Medicine, and the Agency for Healthcare Research and Quality.

These clinical studies will test a care option’s effectiveness in real-life practice situations, such as typical hospital and outpatient care settings, and will involve more diverse patient populations, according to the institute.

The three studies focused on cancer are:


“Enabling a Paradigm Shift: A Preference-Tolerant RCT of Personalized vs. Annual Screening for Breast Cancer.”

The grant includes $14,009,998 for a five-year project headquartered at the … Continue reading 41-08 PCORI Approves $64 Million For Five 2015 Grant Awards

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