Patients with metastatic stomach or esophageal cancers driven by a mutated HER2 gene had markedly improved response rates and survival when Avastin (bevacizumab) was added to a combination of capecitabine and oxaliplatin chemotherapy and Herceptin (trastuzumab).
Last week, FDA granted accelerated approval to Replimune Group Inc. for it’s biologic, RP1 (vusolimogene oderparepvec), following the FDA Cellular, Tissue, and Gene Therapies Advisory Committee’s 10:3 vote in support of the biologic in combination with nivolumab for the treatment of advanced melanoma in patients who have progressed on prior anti-PD-1 therapy.
