AstraZeneca, Pharmacyclics Inc., and Janssen Research & Development LLC to collaborate on MEDI4736 and Imbruvica trials

As USPSTF falters, the idea that “screening is always good” is gaining traction

With the pope’s lung cancer diagnosis jumpstarting conversations about lung cancer screening and the constant buzz surrounding multi-cancer detection tests, evidence-based evaluation of screening tests is more important than ever.

October 21, 2026

Podcast The Directors

VCU’s Baskin and UNC’s Ferris weigh oncology’s looming dilemma—MCDs
Center directors are strategizing for likely FDA approval of GRAIL’s Galleri

As the Galleri test is advancing toward becoming the first multi-cancer detection test to secure FDA approval, cancer care providers are coming up with strategies for using these tests responsibly.

October 16, 2026

Vol.52 No.38

By Sara Willa Ernst and Paul Goldberg

Conversation with The Cancer Letter

As trust in USPSTF erodes, cancer screening is in peril
David Ransohoff predicts a “Wild West” era without evidence-based screening guidelines

The U.S. Preventive Services Task Force is at risk of losing the expertise, evidence-review infrastructure, and institutional culture that has made it a model for evidence-based medicine. In July 2025, David Ransohoff, a gastroenterologist and clinical epidemiologist in the Division of Gastroenterology and Hepatology at University of North Carolina School of Medicine, noted that HHS...

October 16, 2026

Vol.52 No.38

By Claire Marie Porter and Paul Goldberg

Obituary

Rachna Shroff, accomplished GI oncologist and “tireless mentor,” dies at 47
Her endowed award will live on

Rachna Shroff, a physician-scientist who spent much of her career researching treatments for pancreatic and biliary cancers, has died at the age of 47. She briefly battled an aggressive cancer of an unknown origin.

October 16, 2026

Vol.52 No.38

By Claire Marie Porter

News Analysis

The lung cancer diagnosis of Pope Leo—believed to be a never-smoker—sparks conversations around screening
“Even when the patient is the pope, advances in cancer treatment don’t arrive by divine intervention.”

Pope Leo XIV has been diagnosed with lung adenocarcinoma. According to missives from the Holy See, the pope underwent surgery to remove the lower lobe of his right lung Oct. 13.

October 16, 2026

Vol.52 No.38

By Jacquelyn Cobb

Beyond BRCA: Using AI to uncover the hidden architecture of hereditary cancer risk

A Fox Chase Cancer Center team is combining a rare longitudinal family cohort, whole-genome sequencing, AI-guided analysis, and laboratory validation to investigate why people with similar inherited susceptibility can experience very different cancer outcomes.

October 16, 2026

Vol.52 No.38

By Fox Chase Cancer Center

AstraZeneca, Pharmacyclics Inc., and Janssen Research & Development LLC to collaborate on MEDI4736 and Imbruvica trials

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As USPSTF falters, the idea that “screening is always good” is gaining traction

VCU’s Baskin and UNC’s Ferris weigh oncology’s looming dilemma—MCDs
Center directors are strategizing for likely FDA approval of GRAIL’s Galleri

As trust in USPSTF erodes, cancer screening is in peril
David Ransohoff predicts a “Wild West” era without evidence-based screening guidelines

Rachna Shroff, accomplished GI oncologist and “tireless mentor,” dies at 47
Her endowed award will live on

The lung cancer diagnosis of Pope Leo—believed to be a never-smoker—sparks conversations around screening
“Even when the patient is the pope, advances in cancer treatment don’t arrive by divine intervention.”

Beyond BRCA: Using AI to uncover the hidden architecture of hereditary cancer risk

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AstraZeneca, Pharmacyclics Inc., and Janssen Research & Development LLC to collaborate on MEDI4736 and Imbruvica trials

YOU MAY BE INTERESTED IN

As USPSTF falters, the idea that “screening is always good” is gaining traction

VCU’s Baskin and UNC’s Ferris weigh oncology’s looming dilemma—MCDsCenter directors are strategizing for likely FDA approval of GRAIL’s Galleri

As trust in USPSTF erodes, cancer screening is in perilDavid Ransohoff predicts a “Wild West” era without evidence-based screening guidelines

Rachna Shroff, accomplished GI oncologist and “tireless mentor,” dies at 47Her endowed award will live on

The lung cancer diagnosis of Pope Leo—believed to be a never-smoker—sparks conversations around screening“Even when the patient is the pope, advances in cancer treatment don’t arrive by divine intervention.”

Beyond BRCA: Using AI to uncover the hidden architecture of hereditary cancer risk

Never miss an issue!

Login

VCU’s Baskin and UNC’s Ferris weigh oncology’s looming dilemma—MCDs
Center directors are strategizing for likely FDA approval of GRAIL’s Galleri

As trust in USPSTF erodes, cancer screening is in peril
David Ransohoff predicts a “Wild West” era without evidence-based screening guidelines

Rachna Shroff, accomplished GI oncologist and “tireless mentor,” dies at 47
Her endowed award will live on

The lung cancer diagnosis of Pope Leo—believed to be a never-smoker—sparks conversations around screening
“Even when the patient is the pope, advances in cancer treatment don’t arrive by divine intervention.”