Phase III ATLAS, ENVISION clinical trials meet primary endpoints

Combination immunotherapy + chemo is safe and effective for advanced small cell cancers in bladder and prostate

A research team led by UCLA Health Jonsson Comprehensive Cancer Center investigators has shown that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer and small cell/neuroendocrine prostate cancer.

November 15, 2024

Vol.50 No.43

Clinical Roundup

Imfinzi + chemo shows improved EFS and OS in muscle-invasive bladder cancer

Positive results from the NIAGARA phase III trial showed Imfinzi (durvalumab)in combination with chemotherapy demonstrated a statistically significant and clinically meaningful improvement in the primary endpoint of event-free survival and the key secondary endpoint of overall survival versus neoadjuvant chemotherapy for patients with muscle-invasive bladder cancer.

September 20, 2024

Vol.50 No.35

Clinical Roundup

Adjuvant Keytruda prolongs DFS in high-risk bladder cancer

Results from a large phase III clinical trial show that treatment with Keytruda (pembrolizumab) may nearly double the length of time people with high-risk muscle-invasive bladder cancer are cancer-free following surgical removal of the bladder.

September 20, 2024

Vol.50 No.35

Clinical Roundup

UTSW study reveals widespread disparities in immunotherapy use for patients with advanced kidney and bladder cancers

A study led by researchers at UT Southwestern Medical Center reveals significant disparities across the country in the use of immunotherapy for patients with advanced kidney and bladder cancers.

September 06, 2024

Vol.50 No.33

Clinical Roundup

DDR gene mutations associated with complete response to chemo in bladder cancer

Tumors with alterations in any of three specific genes were more likely than other tumors to be eliminated by cisplatin-based chemotherapy.

August 02, 2024

Vol.50 No.31

Drugs & Targets

FDA approves Anktiva for non-muscle-invasive bladder cancer

FDA has approved ImmunityBio’s Anktiva (N-803, or nogapendekin alfa inbakicept-pmln) plus Bacillus Calmette-Guérin for the treatment of patients with BCG-unresponsive non-muscle-invasive bladder cancer with carcinoma in situ, with or without papillary tumors.

April 26, 2024

Vol.50 No.17

Phase III ATLAS, ENVISION clinical trials meet primary endpoints

YOU MAY BE INTERESTED IN

Combination immunotherapy + chemo is safe and effective for advanced small cell cancers in bladder and prostate

Imfinzi + chemo shows improved EFS and OS in muscle-invasive bladder cancer

Adjuvant Keytruda prolongs DFS in high-risk bladder cancer

UTSW study reveals widespread disparities in immunotherapy use for patients with advanced kidney and bladder cancers

DDR gene mutations associated with complete response to chemo in bladder cancer

FDA approves Anktiva for non-muscle-invasive bladder cancer

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