Single-cell based precision oncology: First steps in addressing and overcoming tumor heterogeneity

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Tumor heterogeneity is a well-recognized hurdle to successful cancer therapy, often leading to resistance and treatment failure. 

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Sanju Sinha, PhD
Assistant professor, Cancer Molecular Therapeutics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Eytan Ruppin, MD, PhD
Chief, Data Science Laboratory, Head, Computational Precision Oncology Section, Senior investigator, Center for Cancer Research, National Cancer Institute
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As oncology enters a new era of precision medicine, the Food and Drug Administration’s evolving biomarker strategy aims to ensure that life-saving therapies are tailored to individual patient needs, fostering safer and more effective treatments.  Historically, therapies were approved with broad indications based on overall efficacy, even when outcomes for biomarker-positive and -negative patients were...

Sanju Sinha, PhD
Assistant professor, Cancer Molecular Therapeutics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Eytan Ruppin, MD, PhD
Chief, Data Science Laboratory, Head, Computational Precision Oncology Section, Senior investigator, Center for Cancer Research, National Cancer Institute

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