The Cancer Letter

Inside information on cancer research and drug development

ClinicalTrials & Tribulations

MRI-guided radiotherapy for prostate cancer: Lessons from the MIRAGE trial

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The National Cancer Institute defines precision medicine in cancer as a strategy that “uses specific information about a person’s tumor to help make a diagnosis, plan treatment, find out how well treatment is working, or make a prognosis.”1 

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Byline
Amar U. Kishan, MD
Associate professor, Chief of Genitourinary Oncology Service, Vice chair of clinical and translational research, Department of Radiation Oncology, University of California, Los Angeles
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Talzenna + Xtandi improve OS in metastatic castration-resistant prostate cancer, phase III study finds

Pfizer Inc. announced positive results from the phase III TALAPRO-2 study of Talzenna (talazoparib), an oral poly ADP-ribose polymerase inhibitor, in combination with Xtandi (enzalutamide), an androgen receptor pathway inhibitor, demonstrating a statistically significant and clinically meaningful improvement in overall survival compared to placebo plus Xtandi in patients with metastatic castration-resistant prostate cancer, with or without homologous recombination repair gene mutations.
Byline
Amar U. Kishan, MD
Associate professor, Chief of Genitourinary Oncology Service, Vice chair of clinical and translational research, Department of Radiation Oncology, University of California, Los Angeles
Table of Contents

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