FDA granted accelerated approval to Elrexfio (elranatamab-bcmm), a bispecific B-cell maturation antigen-directed CD3 T-cell engager, for adults with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody.
FDA granted accelerated approval to Talvey (talquetamab-tgvs) for adults with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody.
University of Maryland School of Medicine researchers engineered a type of CAR T-cell therapy that, in preclinical studies, selectively attacked cancer cells while sparing healthy cells, potentially reducing the likelihood of toxic side effects from this innovative cancer treatment.Â
A study demonstrated that exercise may have the power to strengthen the immune system in patients with multiple myeloma.Â
In a first-in-human clinical trial for patients with relapsed multiple myeloma, led by researchers at Indiana University Melvin and Bren Simon Comprehensive Cancer Center, patients treated with higher doses of the immunotherapy called REGN5459 resulted in a 90.5% overall response rate.
Data from the phase III MAIA of Darzalex (daratumumab) in combination with lenalidomide and dexamethasone in newly diagnosed, transplant-ineligible patients with multiple myeloma—regardless of patients’ age and across clinically important subgroups, as well as health-related quality of life among frail TIE patients—were presented in oral and poster presentations at the American Society of Hematology 2022 Annual Meeting.
Positive initial data from a pivotal phase II expansion cohort evaluating investigational linvoseltamab (BCMAXCD3, formerly REGN5458) at the 200 mg dose recommended for further development in patients with heavily pre-treated, relapsed/refractory multiple myeloma, were presented at the 64th American Society of Hematology Annual Meeting and Exposition.Â
Sylvester Comprehensive Cancer Center is building a dedicated Myeloma Research Institute. C. Ola Landgren, who joined Sylvester two years ago, will be the director.
FDA granted accelerated approval to Tecvayli (teclistamab-cqyv), the first bispecific B-cell maturation antigen-directed CD3 T-cell engager, for adult patients with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody.
Research suggests that emergency response personnel, recovery workers, law enforcement, and construction workers who reported to the World Trade Center disaster site were exposed to carcinogens that doubled their risk of developing myeloma.
